{"id":"W2115855364","doi":"10.1002/jps.22809","title":"Rosuvastatin Blocks hERG Current and Prolongs Cardiac Repolarization","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut Universitaire de Cardiologie et de Pneumologie de Québec; Université Laval; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"hERG; Rosuvastatin; Pharmacology; Repolarization; Chemistry; QT interval; Potassium channel; Internal medicine; Medicine; Electrophysiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001858384,0.0004929061,0.0009036112,0.0002071453,0.0001984677,0.0003869789,0.0004083083,0.0005466283,0.001852104],"category_scores_gemma":[0.000423309,0.0001645701,0.0004814886,0.000141732,0.0002459663,0.0004283354,0.0001645928,0.001148207,0.0007783886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000222198,"about_ca_system_score_gemma":0.0003019123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005125216,"about_ca_topic_score_gemma":0.0008592047,"domain_scores_codex":[0.9998275,0.00004232809,0.00002242878,0.00002542999,0.00001956853,0.00006277116],"domain_scores_gemma":[0.9998704,0.00002919673,0.00003861506,0.00002244431,0.00001192338,0.00002736871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01272809,0.0007089901,0.0006736022,0.0004418042,0.0001635423,0.0006348005,0.00008705657,0.0001374093,0.9260111,0.0007626896,0.001878945,0.05577183],"study_design_scores_gemma":[0.00863501,0.01810233,0.01537109,0.00008398202,0.0005533471,0.002902096,0.0002187694,0.002273659,0.9160427,0.001082427,0.03466517,0.00006932571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771581,0.01124772,0.003601085,0.001742125,0.000561448,0.0001747943,0.0005466007,0.000734594,0.004233469],"genre_scores_gemma":[0.9912632,0.004171362,0.001532733,0.0002962629,0.0002123329,0.00005823679,0.000383779,0.00004941153,0.002032734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001852104,"threshold_uncertainty_score":0.006195903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06006615373185656,"score_gpt":0.364732421201283,"score_spread":0.3046662674694264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}