{"id":"W2115859583","doi":"10.15252/embr.201540162","title":"Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages","year":2015,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft; RIKEN; Universität Heidelberg; European Commission; Stem Cell Network; European Molecular Biology Laboratory","keywords":"Biology; Inner cell mass; Embryonic stem cell; Blastocyst; Lineage (genetic); Cell biology; Embryo; Lineage markers; Gene; Embryogenesis; Gene expression profiling; Live cell imaging; Cell fate determination; Cellular differentiation; Gene expression; Cell; Reporter gene; Genetics; Phenotype; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001941493,0.0001989624,0.0001846988,0.00045167,0.0002448276,0.000576203,0.0003849671,0.000372412,0.001983046],"category_scores_gemma":[0.0001744428,0.0005033552,0.0001893596,0.0001589804,0.0003382487,0.0004791488,0.0003871412,0.0009963784,0.0006115661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003682439,"about_ca_system_score_gemma":0.0003209763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046261,"about_ca_topic_score_gemma":0.002637934,"domain_scores_codex":[0.9998808,0.00001076552,0.000004642616,0.0000383693,0.00002681895,0.00003857204],"domain_scores_gemma":[0.9998496,0.00003493358,0.00003940125,0.00001497442,0.00001001489,0.00005102014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001041411,0.0000047552,0.0003524997,0.00002241427,0.000003437411,0.00006578113,0.00003159511,0.0001389913,0.9955236,0.001976248,0.00006953884,0.001707068],"study_design_scores_gemma":[0.00001795467,0.00005618408,0.008600953,0.00001806779,0.00001074004,0.0003419367,0.0000538889,0.002621729,0.9845759,0.0005308367,0.003161443,0.00001039414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698182,0.001782852,0.02177651,0.0001801402,0.00004770196,0.00001761971,0.0006034848,0.0002444956,0.005528985],"genre_scores_gemma":[0.974788,0.001066409,0.01033843,0.00009722634,0.00001594655,0.000038849,0.0006586052,0.0002332697,0.01276338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001983046,"threshold_uncertainty_score":0.006633937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04071661082338996,"score_gpt":0.3021937314346547,"score_spread":0.2614771206112648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}