{"id":"W2115872602","doi":"10.1093/cid/cir493","title":"Deep V3 Sequencing for HIV Type 1 Tropism in Treatment-Naive Patients: A Reanalysis of the MERIT Trial of Maraviroc","year":2011,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; AIDS Vancouver","funders":"","keywords":"Maraviroc; Medicine; CCR5 receptor antagonist; Efavirenz; Regimen; Tropism; Human immunodeficiency virus (HIV); Internal medicine; Virology; Oncology; Viral load; Antiretroviral therapy; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300954,0.0001263796,0.0004772699,0.00008240807,0.00006658467,0.000002600584,0.0001307479,0.0001284829,0.0001856711],"category_scores_gemma":[0.001168855,0.00007800395,0.0004543513,0.0001844281,0.0003498181,0.00003649505,0.00004636955,0.00009273181,0.00005209159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009780409,"about_ca_system_score_gemma":0.0001677571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000372164,"about_ca_topic_score_gemma":0.0002729769,"domain_scores_codex":[0.9984956,0.0004344542,0.0005806729,0.0002304304,0.00004075713,0.0002181202],"domain_scores_gemma":[0.9985785,0.000666883,0.0002408727,0.0003319832,0.0001401194,0.00004164132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01071789,0.005387464,0.9711913,0.00002420932,0.001152735,0.000002600165,0.0002359874,0.000004438494,0.0002158113,0.0001168277,0.0002243238,0.01072639],"study_design_scores_gemma":[0.113672,0.01581992,0.8617821,0.00007729808,0.001574078,0.000001226682,0.0002229536,0.00001776559,0.003653446,0.001632655,0.001308316,0.0002381567],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976693,0.0004644839,0.00003004327,0.00002101374,0.0003184599,0.0008317803,0.0002402674,0.00002002043,0.0004046468],"genre_scores_gemma":[0.9992428,0.0002299978,0.00001255742,0.00002130717,0.00002582148,0.0001196238,0.000134713,0.00001202061,0.0002011932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1094092,"threshold_uncertainty_score":0.3180909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06462040065548122,"score_gpt":0.3432630769226386,"score_spread":0.2786426762671573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}