{"id":"W2115872602","doi":"10.1093/cid/cir493","title":"Deep V3 Sequencing for HIV Type 1 Tropism in Treatment-Naive Patients: A Reanalysis of the MERIT Trial of Maraviroc","year":2011,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; AIDS Vancouver","funders":"","keywords":"Maraviroc; Medicine; CCR5 receptor antagonist; Efavirenz; Regimen; Tropism; Human immunodeficiency virus (HIV); Internal medicine; Virology; Oncology; Viral load; Antiretroviral therapy; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007558429,0.0004291764,0.001149432,0.0004456267,0.0002344421,0.0009440675,0.0004442738,0.0003199528,0.001017969],"category_scores_gemma":[0.006681907,0.0002258718,0.001314022,0.0004210827,0.0003463794,0.0003263132,0.0005541816,0.0007020721,0.0001950395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006071274,"about_ca_system_score_gemma":0.0006983212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007774245,"about_ca_topic_score_gemma":0.001309772,"domain_scores_codex":[0.9974369,0.001443891,0.0001368733,0.0002806048,0.0005215201,0.0001802557],"domain_scores_gemma":[0.9957544,0.001622611,0.0009127086,0.0007619099,0.0006130338,0.0003354519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0992745,0.0006681355,0.5773994,0.0009964664,0.005436692,0.0007251128,0.000846719,0.0159196,0.06124356,0.001222204,0.009650797,0.2266168],"study_design_scores_gemma":[0.005889757,0.01862172,0.8841642,0.0003002288,0.004147459,0.001963373,0.0003450206,0.04477749,0.01833324,0.002606154,0.01873774,0.000113776],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989903,0.002220124,0.004109101,0.0003654544,0.00004263752,0.000203856,0.001736105,0.00006248522,0.00135732],"genre_scores_gemma":[0.9934104,0.0001952449,0.002777959,0.0002537681,0.00004188925,0.0001198712,0.002755763,0.0000265649,0.000418503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007558429,"threshold_uncertainty_score":0.03997332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06462040065548122,"score_gpt":0.3432630769226386,"score_spread":0.2786426762671573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}