{"id":"W2115880540","doi":"10.1128/mcb.01517-12","title":"Inactivation of the mTORC1-Eukaryotic Translation Initiation Factor 4E Pathway Alters Stress Granule Formation","year":2013,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"EIF4E; mTORC1; Stress granule; Eukaryotic initiation factor; Biology; Cell biology; Initiation factor; PI3K/AKT/mTOR pathway; Eukaryotic translation; EIF4EBP1; Phosphorylation; Translation (biology); Signal transduction; Integrated stress response; P70-S6 Kinase 1; Biochemistry; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008906756,0.0001454791,0.0001321556,0.00004857588,0.0000743882,0.00001650086,0.0001366938,0.0002026362,0.00002688124],"category_scores_gemma":[0.00003484926,0.000116318,0.00008682381,0.0000935029,0.0001047838,0.00001734896,0.00004281095,0.00008574309,0.000003074394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001981687,"about_ca_system_score_gemma":0.00003949308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006469985,"about_ca_topic_score_gemma":0.00001273061,"domain_scores_codex":[0.9990559,0.0001771,0.0002552206,0.0002384361,0.000099087,0.0001742642],"domain_scores_gemma":[0.9994191,0.00001508864,0.0001709212,0.0002535092,0.0001018911,0.00003950557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001805495,0.0000232984,0.002313315,0.0000352516,0.0000257249,2.681228e-7,0.0001162701,0.00009278236,0.9918246,0.0002389872,0.00002074649,0.005290678],"study_design_scores_gemma":[0.0004086008,0.0001830659,0.002687721,0.00001770763,0.00001670435,0.000003152033,0.00004340344,0.0004009077,0.9949921,0.0005713608,0.0005386086,0.0001366996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9382721,0.0008678207,0.05994244,0.0001220306,0.0001565606,0.0003618461,0.00003648482,0.000009138864,0.0002316542],"genre_scores_gemma":[0.9991083,0.00003917208,0.0001788071,0.0001678779,0.00005910071,0.00004202774,0.0003688147,0.0000163634,0.00001960571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0608362,"threshold_uncertainty_score":0.4743312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01153728553006722,"score_gpt":0.218856146268603,"score_spread":0.2073188607385358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}