{"id":"W2115922451","doi":"10.1128/aac.00949-15","title":"Effective Inhibition of HIV-1 Production by Short Hairpin RNAs and Small Interfering RNAs Targeting a Highly Conserved Site in HIV-1 Gag RNA Is Optimized by Evaluating Alternative Length Formats","year":2015,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Small interfering RNA; Small hairpin RNA; RNA interference; Biology; RNA; Dicer; Trans-acting siRNA; Small nucleolar RNA; Computational biology; Ribozyme; Molecular biology; Cell biology; Genetics; Long non-coding RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007334306,0.000679863,0.0004929004,0.0003128955,0.0001877552,0.0005863517,0.0003259469,0.0003545928,0.0005589334],"category_scores_gemma":[0.0004532378,0.0002647677,0.0003242488,0.0002077024,0.0002947893,0.0003384034,0.0002617278,0.0006124577,0.000223986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004208162,"about_ca_system_score_gemma":0.0002465495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001936082,"about_ca_topic_score_gemma":0.0005759274,"domain_scores_codex":[0.9993373,0.0001615971,0.0001173899,0.00009089206,0.0002330399,0.00005987619],"domain_scores_gemma":[0.9996415,0.0001142268,0.0001165459,0.00003812106,0.00005092606,0.00003862968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004189095,0.00004105392,0.00007438585,0.00004189934,0.000005203432,0.00001686954,0.000008957987,0.0002643729,0.9984724,0.00007580894,0.00001187856,0.0009452516],"study_design_scores_gemma":[0.000009056923,0.0004014349,0.0002507566,0.000002630461,0.00001222105,0.00003341483,0.000004952392,0.0007501654,0.9980463,0.00001837792,0.0004667287,0.000003919507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805282,0.002033031,0.01531887,0.00005118856,0.00003520629,0.0001835207,0.0001833224,0.00009647953,0.001570329],"genre_scores_gemma":[0.9588543,0.001659917,0.03744749,0.00005624349,0.00002202336,0.0002092068,0.0003605165,0.00004317651,0.001347026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007334306,"threshold_uncertainty_score":0.003878832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01889679984942683,"score_gpt":0.2658367834499547,"score_spread":0.2469399836005279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}