{"id":"W2115935336","doi":"10.1128/mcb.01127-06","title":"Mutant Myocilin Nonsecretion In Vivo Is Not Sufficient To Cause Glaucoma","year":2006,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Stroke Network; National Eye Institute; Howard Hughes Medical Institute","keywords":"Myocilin; Glaucoma; Mutant; Biology; Intraocular pressure; Mutation; Open angle glaucoma; Trabecular meshwork; Cell biology; Genetics; Ophthalmology; Gene; Medicine; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003305161,0.0004516829,0.0003383145,0.0003969358,0.0001639822,0.0003793318,0.0002685927,0.000598422,0.001344121],"category_scores_gemma":[0.0004918433,0.0002554137,0.0002678861,0.0001456129,0.0004458489,0.0002686746,0.0003148162,0.0006971293,0.000509824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002739394,"about_ca_system_score_gemma":0.0003073929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004028837,"about_ca_topic_score_gemma":0.0004734087,"domain_scores_codex":[0.9996297,0.00007239638,0.00005553259,0.00006247307,0.0001259764,0.00005389995],"domain_scores_gemma":[0.9991066,0.0002413673,0.00025475,0.0001258538,0.00004917232,0.0002222569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000989414,0.00003293042,0.0003641499,0.00002097767,0.000009787143,0.0001171437,0.00000836354,0.00004198895,0.9986571,0.000153111,0.0000628592,0.0004326868],"study_design_scores_gemma":[0.0000553973,0.000504013,0.009393905,0.00001605487,0.0000368085,0.001948575,0.0000376313,0.001223603,0.9826064,0.0002191409,0.003948545,0.00001002322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932112,0.002146866,0.002099313,0.0003164774,0.0001200524,0.000030212,0.0005136119,0.0001465117,0.00141567],"genre_scores_gemma":[0.9943224,0.0007528188,0.001968299,0.0001793924,0.00002984045,0.0000336616,0.0008177289,0.00008416858,0.00181163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001344121,"threshold_uncertainty_score":0.004496515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006101453912651794,"score_gpt":0.2327195101422258,"score_spread":0.226618056229574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}