{"id":"W2115935336","doi":"10.1128/mcb.01127-06","title":"Mutant Myocilin Nonsecretion In Vivo Is Not Sufficient To Cause Glaucoma","year":2006,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Stroke Network; National Eye Institute; Howard Hughes Medical Institute","keywords":"Myocilin; Glaucoma; Mutant; Biology; Intraocular pressure; Mutation; Open angle glaucoma; Trabecular meshwork; Cell biology; Genetics; Ophthalmology; Gene; Medicine; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303081,0.0001543721,0.0002466882,0.0001579472,0.00004470356,0.000008221406,0.00005391757,0.0001646145,0.00009955063],"category_scores_gemma":[0.00002167052,0.0001299842,0.0000772563,0.0001922051,0.00008911907,0.000007909771,0.00004542835,0.0001275202,0.00003229572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002932583,"about_ca_system_score_gemma":0.00003148253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006355739,"about_ca_topic_score_gemma":0.00008964281,"domain_scores_codex":[0.9989359,0.00007224677,0.0002361792,0.0003477722,0.00009825818,0.0003096937],"domain_scores_gemma":[0.999616,0.00001435561,0.00003188671,0.000197944,0.00003692636,0.0001028456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001560732,0.0001382572,0.07022729,0.00002341483,0.00001375787,0.0003756669,0.0001304859,0.000001146956,0.9269987,0.001503231,0.0001499632,0.0002820032],"study_design_scores_gemma":[0.001793436,0.0009206959,0.0616979,0.00005120681,0.00007975672,0.0001317951,0.0001967802,0.0004013892,0.9116891,0.0004268011,0.02231222,0.0002989372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909018,0.0007459049,0.004400266,0.002456802,0.00008427788,0.0003475169,0.00001235275,0.00002279744,0.001028294],"genre_scores_gemma":[0.9973143,0.00002336153,0.0002261729,0.002016206,0.00002893339,0.0000158691,0.00005450289,0.0000152545,0.0003053894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02216226,"threshold_uncertainty_score":0.5300603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006101453912651794,"score_gpt":0.2327195101422258,"score_spread":0.226618056229574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}