{"id":"W2115956491","doi":"10.1091/mbc.e02-06-0322","title":"Peroxisome Senescence in Human Fibroblasts","year":2002,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Peroxisome; Biology; Organelle; Biogenesis; Cell biology; Catalase; Reactive oxygen species; Peroxisome proliferator-activated receptor gamma; Biochemistry; Senescence; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168889,0.0001879234,0.0001934558,0.00006675785,0.00006049243,0.000005591924,0.0005217302,0.0002829085,0.00007378699],"category_scores_gemma":[0.00004794918,0.000148843,0.0001406752,0.0001833014,0.0002668186,0.000002610846,0.0002612424,0.0001742905,0.00001440813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001868252,"about_ca_system_score_gemma":0.0000176742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001687705,"about_ca_topic_score_gemma":0.00000863385,"domain_scores_codex":[0.9987603,0.0002105489,0.0002576574,0.0003754217,0.00008427812,0.0003117476],"domain_scores_gemma":[0.9992205,0.000007484675,0.0001225197,0.0005565885,0.00004050504,0.00005242099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001117259,0.0001081449,0.01207601,0.00001601445,0.00001644015,0.000001993052,0.00003507547,0.00007442164,0.9871931,0.00005276725,0.0002785141,0.0001363099],"study_design_scores_gemma":[0.0004532788,0.0001776359,0.0005265301,0.00001656208,0.000006091802,0.000007837726,0.00001436387,0.00003493739,0.9964774,0.0001233304,0.001994053,0.0001679907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996384,0.001207161,0.0002817256,0.0001997969,0.0001358409,0.0001833251,0.000009029653,0.000009258535,0.001589891],"genre_scores_gemma":[0.9987555,0.00006405233,0.0002585122,0.0002260418,0.00003931106,0.00001432654,0.00001705907,0.00002408262,0.0006011142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01154948,"threshold_uncertainty_score":0.6069642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007317938041362394,"score_gpt":0.2302030686424779,"score_spread":0.2228851306011155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}