{"id":"W2115979125","doi":"10.3390/cancers6020879","title":"lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK","year":2014,"lang":"en","type":"article","venue":"Cancers","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Health and Medical Research Council; Medical Research Council","keywords":"Cell biology; Hippo signaling pathway; Biology; Kinase; Phosphorylation; Protein kinase A; Merlin (protein); Programmed cell death; Signal transduction; Protein phosphatase 2; MAPK/ERK pathway; Hedgehog signaling pathway; Suppressor; Cell growth; Phosphatase; Apoptosis; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000299695,0.000167225,0.0001872423,0.00003151234,0.0001083678,0.00002513337,0.0002316454,0.0001701252,0.00002507339],"category_scores_gemma":[0.00008362447,0.0001252627,0.00008318749,0.00008309306,0.0002207802,0.000004432589,0.00007749102,0.0001254996,0.000004271244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003607732,"about_ca_system_score_gemma":0.0001999239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001593958,"about_ca_topic_score_gemma":0.00007714257,"domain_scores_codex":[0.9989429,0.0001007473,0.0002216113,0.0003273136,0.0001565534,0.0002509199],"domain_scores_gemma":[0.9992732,0.00003428307,0.0001301938,0.0004012831,0.00006637154,0.00009464505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006442775,0.000009372196,0.002159545,0.00003282683,0.00006484435,0.00000118537,0.0002541845,0.0003797669,0.9791372,0.0003574608,0.0006340016,0.01690519],"study_design_scores_gemma":[0.0007408126,0.0003249136,0.0008080829,0.00004524949,0.00002988193,0.00001049766,0.0003409871,0.0003596842,0.9448287,0.0005739947,0.05169463,0.000242509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952974,0.002038727,0.0003684002,0.0001107846,0.0002030243,0.0001356913,0.00003269091,0.00001526257,0.001798014],"genre_scores_gemma":[0.9982012,0.0002081112,0.0001078734,0.0002673366,0.0002889864,0.00001783201,0.00004691595,0.00002273344,0.0008390438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05106062,"threshold_uncertainty_score":0.5108065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00753571372967581,"score_gpt":0.2183357147347801,"score_spread":0.2108000010051042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}