{"id":"W2115983165","doi":"10.1073/pnas.0912344107","title":"Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Vesicular stomatitis virus; Oncolytic virus; P70-S6 Kinase 1; Biology; PI3K/AKT/mTOR pathway; Virology; Interferon; mTORC1; Virus; Cancer research; Cell biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001261628,0.0003138829,0.0002467904,0.000187188,0.00008747671,0.0002308183,0.0001071482,0.0001750367,0.0006478695],"category_scores_gemma":[0.00007098683,0.0001053931,0.0001810031,0.00009509681,0.0002089562,0.0001251455,0.0001412628,0.0003669563,0.0001675578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000227621,"about_ca_system_score_gemma":0.0001503175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003202195,"about_ca_topic_score_gemma":0.0005527889,"domain_scores_codex":[0.999891,0.00002307898,0.00001274498,0.00001705861,0.00002679203,0.00002925815],"domain_scores_gemma":[0.999952,0.000009554786,0.00001861912,0.000005843259,0.000003222553,0.00001078254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001178738,0.00002155775,0.0001174532,0.00001833202,0.000004256535,0.00001826358,0.00000391481,0.00007049343,0.9984609,0.00007882551,0.00002212006,0.001065971],"study_design_scores_gemma":[0.00001204776,0.0003766278,0.001665594,0.000003026416,0.00001213406,0.0001138288,0.000006595969,0.000421303,0.9964991,0.00002572518,0.0008623342,0.00000172817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964184,0.001224901,0.00087273,0.00007315105,0.00002446984,0.00001343593,0.0001511819,0.00004784365,0.001173983],"genre_scores_gemma":[0.9975938,0.0007075925,0.0007973084,0.00002218371,0.000007880541,0.00001236496,0.0001720793,0.000007959545,0.0006788988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006478695,"threshold_uncertainty_score":0.002167344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02086390020905851,"score_gpt":0.3154584232902004,"score_spread":0.2945945230811419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}