{"id":"W2115984783","doi":"10.1186/1472-684x-8-14","title":"An open-label, 1-year extension study of the long-term safety and efficacy of once-daily OROS® hydromorphone in patients with chronic cancer pain","year":2009,"lang":"en","type":"article","venue":"BMC Palliative Care","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Johnson and Johnson; London Health Sciences Centre","keywords":"Hydromorphone; Medicine; Dosing; Opioid; Chronic pain; Anesthesia; Cancer pain; Morphine; Analgesic; Cancer; Internal medicine; Physical therapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003559923,0.001315308,0.002301367,0.0004755289,0.0006110133,0.0006757826,0.0008901572,0.00109185,0.003090457],"category_scores_gemma":[0.002496024,0.0005269485,0.00148767,0.0003911512,0.001325698,0.001210222,0.0004998532,0.002414302,0.0006406014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007301196,"about_ca_system_score_gemma":0.001346317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009221748,"about_ca_topic_score_gemma":0.001295338,"domain_scores_codex":[0.9987961,0.0005649969,0.00009095632,0.0001982235,0.0001308204,0.0002188021],"domain_scores_gemma":[0.9969444,0.0006799411,0.0009034474,0.0004069578,0.0002259265,0.0008393467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7645714,0.139108,0.01407148,0.0005197736,0.0008243615,0.000189674,0.000536477,0.000680216,0.02265572,0.00007766188,0.0007877459,0.05597746],"study_design_scores_gemma":[0.2088996,0.7629684,0.0258575,0.00001457044,0.0002107543,0.0001201439,0.00004870077,0.0003284676,0.001046306,0.00002950864,0.000455564,0.00002052456],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983131,0.0003727473,0.0001438806,0.00005055263,0.00002625629,0.0006323579,0.0001769733,0.00001738803,0.0002667271],"genre_scores_gemma":[0.9965186,0.0003260476,0.0006008359,0.000213057,0.0001580704,0.0009370834,0.0006052741,0.000007270365,0.0006336217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003559923,"threshold_uncertainty_score":0.01882684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0307402258035856,"score_gpt":0.3207875473449446,"score_spread":0.290047321541359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}