{"id":"W2115997974","doi":"10.1002/jcb.22867","title":"PTEN suppression promotes neurite development exclusively in differentiating PC12 cells via PI3‐kinase and MAP kinase signaling","year":2010,"lang":"en","type":"article","venue":"Journal of Cellular Biochemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Royal Ottawa Mental Health Centre; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"PTEN; Neurite; Phosphatase; Cell biology; Protein kinase B; Gene knockdown; Gene silencing; Biology; Phosphorylation; PI3K/AKT/mTOR pathway; Signal transduction; Cell culture; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008665866,0.0004643784,0.0003022426,0.0002790004,0.0002196884,0.0002812846,0.0001962154,0.0001684748,0.0008155296],"category_scores_gemma":[0.00007318348,0.0001432851,0.0002930603,0.0002459775,0.0002532703,0.0001730283,0.000268982,0.0005995159,0.0003760075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003093268,"about_ca_system_score_gemma":0.0005265215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003772536,"about_ca_topic_score_gemma":0.008228806,"domain_scores_codex":[0.9998908,0.000008242248,0.00001242093,0.00001830051,0.00004349861,0.00002674028],"domain_scores_gemma":[0.999925,0.000009569594,0.00001505643,0.000009154738,0.0000102518,0.00003102841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007866703,0.00001721435,0.00009221426,0.00002923232,0.000003662421,0.00005240994,0.00001350443,0.00003910437,0.9986558,0.00008577308,0.00002955034,0.000902882],"study_design_scores_gemma":[0.00001214104,0.0001504841,0.003059292,0.000004158072,0.00001819533,0.0001276412,0.00001979721,0.0006369582,0.9940546,0.00004769462,0.001865249,0.000003814861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929646,0.001452682,0.002387624,0.00008773767,0.00003115557,0.00002476721,0.0004808556,0.0001553796,0.002415194],"genre_scores_gemma":[0.9887245,0.001939058,0.003208821,0.00003239466,0.000007915291,0.00005100673,0.0007580614,0.00003484323,0.005243314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003772536,"threshold_uncertainty_score":0.007501125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005897305975561055,"score_gpt":0.2232420819936097,"score_spread":0.2173447760180487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}