{"id":"W2115999215","doi":"10.1084/jem.20080178","title":"A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease","year":2008,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":641,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute for Health and Care Research; Wellcome Trust","keywords":"Immune system; Huntington's disease; Microglia; Huntingtin; Biology; Immunology; Innate immune system; Neuroimmunology; Inflammation; Disease; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001274513,0.000212028,0.0002725667,0.0003380784,0.0001730403,0.0003075454,0.000108998,0.0003503352,0.001602794],"category_scores_gemma":[0.0003009286,0.00009513699,0.0001043464,0.000144886,0.0002907557,0.0001973379,0.0002438063,0.0003827833,0.0001964987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001463141,"about_ca_system_score_gemma":0.0001087251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001626469,"about_ca_topic_score_gemma":0.0002158152,"domain_scores_codex":[0.9999427,0.00001273026,0.000005633392,0.00001691213,0.000008911819,0.00001310389],"domain_scores_gemma":[0.9998267,0.00003586851,0.00006957425,0.00001325037,0.00001957545,0.00003508403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002474076,0.0002279385,0.08785766,0.0001507642,0.00003048029,0.02035802,0.0003154471,0.0001519212,0.8691778,0.0009530445,0.0005038521,0.01779899],"study_design_scores_gemma":[0.00018843,0.002229376,0.8354868,0.0001046814,0.00009508873,0.07330251,0.0003671102,0.001384539,0.08114169,0.002218489,0.003449781,0.00003144312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967507,0.001290538,0.0007672318,0.00006795557,0.00001029551,0.00001223582,0.0001190453,0.00003660237,0.0009453407],"genre_scores_gemma":[0.9982792,0.000350531,0.0007529713,0.00006221706,0.00002177104,0.00001084984,0.0001582863,0.000004526726,0.0003596687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602794,"threshold_uncertainty_score":0.005361915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05972563675676124,"score_gpt":0.3328210045367076,"score_spread":0.2730953677799464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}