{"id":"W2116004391","doi":"10.1146/annurev-pharmtox-010611-134529","title":"Drug Transporters in Drug Efficacy and Toxicity","year":2011,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":354,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Drug; ATP-binding cassette transporter; Transporter; Pharmacology; Efflux; Biology; Drug metabolism; Efficacy; Drug development; Computational biology; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001371708,0.0004830591,0.003350966,0.0002037163,0.00007252057,0.000002174295,0.0002910451,0.0003102098,0.0003799791],"category_scores_gemma":[0.00002719188,0.0002875237,0.0003402853,0.0003084101,0.0007159681,0.00005587514,0.00006170297,0.0008938636,0.000009706155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003209401,"about_ca_system_score_gemma":0.0002597637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001841427,"about_ca_topic_score_gemma":0.00004687372,"domain_scores_codex":[0.9972861,0.0005503423,0.001107556,0.0005070363,0.0001191979,0.0004298141],"domain_scores_gemma":[0.9986755,0.0003890685,0.0004553501,0.0002586824,0.00006803148,0.0001533983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000327459,0.0006862949,0.0000185808,0.2771554,0.0006937206,0.0003454014,0.001382941,3.777498e-8,0.00008181191,0.001460128,0.005963288,0.7118849],"study_design_scores_gemma":[0.001360978,0.0002316811,0.00007514224,0.03811377,0.005751307,0.0002493922,0.00007678709,2.008488e-7,0.0001108586,0.00007303109,0.9536856,0.0002712834],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001448902,0.9934096,0.000002923738,0.001065883,0.0004151303,0.00244211,0.00008052011,0.00002172734,0.00111324],"genre_scores_gemma":[0.001096632,0.9952394,0.0000411925,0.002620909,0.0001295798,0.000160583,0.00004879392,0.00003761123,0.000625345],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9477223,"threshold_uncertainty_score":0.9999577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02623551943710283,"score_gpt":0.3512868675268911,"score_spread":0.3250513480897883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}