{"id":"W2116015677","doi":"10.1101/gr.195305.115","title":"Replication timing is regulated by the number of MCMs loaded at origins","year":2015,"lang":"en","type":"article","venue":"Genome Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Biology; Replication timing; Pre-replication complex; Replication (statistics); Minichromosome maintenance; Origin recognition complex; Control of chromosome duplication; DNA replication; Origin of replication; DNA replication factor CDT1; Genetics; Chromatin; Licensing factor; Genome; Cell biology; Eukaryotic DNA replication; DNA; Gene; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001465826,0.00007856447,0.0000890905,0.00002971454,0.00009748783,0.00001599695,0.0003866625,0.0001250041,0.0001179866],"category_scores_gemma":[0.0001792731,0.00006055385,0.00004626518,0.0002232026,0.0001281832,0.000002636632,0.0003466624,0.0001157062,0.0001890209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001071809,"about_ca_system_score_gemma":0.0001175841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009658452,"about_ca_topic_score_gemma":0.000003878362,"domain_scores_codex":[0.9985682,0.0001685252,0.0001629178,0.0003717288,0.0004294253,0.0002992105],"domain_scores_gemma":[0.9983147,0.00001827355,0.00005350943,0.001147795,0.0003592627,0.000106466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006281215,0.00002645885,0.0002753705,0.00000865299,0.00002700203,6.760215e-7,0.0001728589,0.000004075523,0.9782417,0.0001322722,0.0202917,0.0007563759],"study_design_scores_gemma":[0.0002158159,0.00008095137,0.0001588704,0.000003188332,0.000003449468,0.00001493761,0.00009437383,0.00005471965,0.8118088,0.0002714889,0.1872321,0.00006134572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930343,0.0005670228,0.0002104819,0.0006480323,0.00003255977,0.0002723753,0.00002719106,0.00001039306,0.00519762],"genre_scores_gemma":[0.9789208,0.00006452041,0.0003606568,0.00006957421,0.00008260327,0.0000372262,0.0001544884,0.00002275014,0.02028741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1669404,"threshold_uncertainty_score":0.2469314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08828534143864791,"score_gpt":0.3816387544376447,"score_spread":0.2933534129989968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}