{"id":"W2116015677","doi":"10.1101/gr.195305.115","title":"Replication timing is regulated by the number of MCMs loaded at origins","year":2015,"lang":"en","type":"article","venue":"Genome Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Biology; Replication timing; Pre-replication complex; Replication (statistics); Minichromosome maintenance; Origin recognition complex; Control of chromosome duplication; DNA replication; Origin of replication; DNA replication factor CDT1; Genetics; Chromatin; Licensing factor; Genome; Cell biology; Eukaryotic DNA replication; DNA; Gene; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004453082,0.0002481702,0.0004564484,0.0005192049,0.000328345,0.001082033,0.0004217129,0.0004569529,0.001539546],"category_scores_gemma":[0.00155366,0.0004234912,0.0002718662,0.0002694391,0.0004703873,0.0006198369,0.0006865155,0.0006044725,0.0006522254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006358827,"about_ca_system_score_gemma":0.0002823612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008544193,"about_ca_topic_score_gemma":0.001147692,"domain_scores_codex":[0.9994149,0.00005674803,0.00004189584,0.0002409519,0.000162632,0.00008285075],"domain_scores_gemma":[0.9986693,0.0003921976,0.0004019435,0.000204497,0.00012833,0.0002038461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001169572,0.00001197158,0.003122492,0.0000244413,0.000009317792,0.00003142695,0.00002357128,0.0005430839,0.9927309,0.0005134994,0.00002788868,0.002844392],"study_design_scores_gemma":[0.00001944717,0.0001673232,0.05740008,0.00001864429,0.0000339525,0.0004324569,0.0001003489,0.01539512,0.9227557,0.000964997,0.002671334,0.00004050354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845734,0.00164097,0.01182172,0.00007599476,0.0000267692,0.000008727591,0.0001753441,0.0001378216,0.001539226],"genre_scores_gemma":[0.9959599,0.0002691634,0.002927196,0.00001689563,0.00001083891,0.000007558642,0.0001375269,0.00004057006,0.0006303688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001539546,"threshold_uncertainty_score":0.005150318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08828534143864791,"score_gpt":0.3816387544376447,"score_spread":0.2933534129989968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}