{"id":"W2116026085","doi":"10.1093/nar/gki278","title":"Target-dependent on/off switch increases ribozyme fidelity","year":2005,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Ribozyme; Ligase ribozyme; Biology; RNA; Riboswitch; Mammalian CPEB3 ribozyme; Computational biology; RNA interference; Hairpin ribozyme; Cleave; Cleavage (geology); Aptamer; Gene; Genetics; Cell biology; Non-coding RNA; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002976098,0.000321378,0.0003220924,0.000175272,0.00008240069,0.0004785941,0.0003378554,0.0003484413,0.002272204],"category_scores_gemma":[0.0005056481,0.0001642104,0.0001744891,0.00008046065,0.0002652842,0.0003591031,0.0003354648,0.0005394156,0.000382728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001857234,"about_ca_system_score_gemma":0.0001291594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001081452,"about_ca_topic_score_gemma":0.0001263309,"domain_scores_codex":[0.9996881,0.00003426093,0.00002306576,0.00009245117,0.00009947597,0.00006248911],"domain_scores_gemma":[0.99962,0.0001411557,0.00008673218,0.00005962152,0.00003681768,0.00005565966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004726508,0.00002716502,0.0001169208,0.00001772997,0.000002528522,0.00002775279,0.0000155835,0.0001189776,0.9957415,0.00047352,0.00003621314,0.003374955],"study_design_scores_gemma":[0.000008475459,0.0001216151,0.0005429951,0.000002299181,0.000004910171,0.00007620162,0.000006537539,0.001505627,0.9964629,0.0001269261,0.001138199,0.000003429817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760072,0.0003830909,0.01619683,0.0001052035,0.00006539236,0.00003338567,0.00005768423,0.0004720595,0.006679196],"genre_scores_gemma":[0.9952363,0.00011602,0.002497614,0.00006777619,0.00001210067,0.00001173099,0.00004801608,0.0000585255,0.001951948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002272204,"threshold_uncertainty_score":0.007601321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03331310042999279,"score_gpt":0.3263232631944786,"score_spread":0.2930101627644858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}