{"id":"W2116080645","doi":"10.1016/j.neurobiolaging.2013.07.013","title":"The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants","year":2013,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; Yonsei University College of Medicine; Centre hospitalier régional universitaire de Lille; Michael J. Fox Foundation for Parkinson's Research; Parkinson Vereniging; Institut National de la Santé et de la Recherche Médicale; University of Thessaly; Svenska Läkaresällskapet; Association France Parkinson; Svenska Sällskapet för Medicinsk Forskning; Vetenskapsrådet; Parkinsonfonden; Ministero della Salute; Università degli Studi di Milano-Bicocca; Agence Nationale de la Recherche; Hermann und Lilly Schilling-Stiftung für Medizinische Forschung; Canada Excellence Research Chairs, Government of Canada; Karolinska Institutet; Yonsei University; Fondation de France; Bundesministerium für Bildung und Forschung; Griffith University; Skånes universitetssjukhus; Genome British Columbia; National Institutes of Health; Volkswagen Foundation; Eli Lilly and Company","keywords":"LRRK2; Haplotype; Genetics; Parkinson's disease; Tau protein; Genotype; Biology; Disease; Gene; Alzheimer's disease; Medicine; Internal medicine; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004137612,0.001210701,0.000949678,0.0004206666,0.0005148857,0.0004680447,0.0005754006,0.001495019,0.006935153],"category_scores_gemma":[0.001567808,0.000315225,0.001142564,0.0003865211,0.0004846882,0.0005109371,0.0004266904,0.0008857192,0.0007170622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001977237,"about_ca_system_score_gemma":0.0002776331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002473642,"about_ca_topic_score_gemma":0.002178614,"domain_scores_codex":[0.9996306,0.00007324418,0.00003505306,0.0001453638,0.00005576269,0.0000600016],"domain_scores_gemma":[0.9993611,0.0001857828,0.0002228899,0.00006943979,0.00004623627,0.0001145318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.05504455,0.0009513916,0.2864487,0.0006859043,0.006735034,0.02479854,0.0005262468,0.002068058,0.5368819,0.003411258,0.00788034,0.07456816],"study_design_scores_gemma":[0.001490957,0.003812694,0.9283444,0.000139389,0.005013675,0.01985946,0.0002153678,0.003039203,0.02273932,0.004175673,0.01103693,0.0001329727],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875762,0.002282381,0.001247679,0.00104417,0.0002959778,0.00002671458,0.001622147,0.0001908689,0.005713821],"genre_scores_gemma":[0.9968209,0.0004456619,0.0005195192,0.0002769102,0.0001805252,0.00001437981,0.0004817091,0.00006632606,0.00119404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006935153,"threshold_uncertainty_score":0.02320039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006796064664799881,"score_gpt":0.2358592801668831,"score_spread":0.2290632155020832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}