{"id":"W2116103937","doi":"10.1093/carcin/bgi371","title":"Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells","year":2005,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bell (Canada)","funders":"","keywords":"Ceramide; Curcumin; Apoptosis; Sphingomyelin; Programmed cell death; Reactive oxygen species; Lipid signaling; Cell biology; Signal transduction; Acid sphingomyelinase; Chemistry; Sphingolipid; Cancer cell; Cell culture; Biology; Biochemistry; Cancer research; Cancer; Receptor; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001214801,0.00049517,0.0003257068,0.0003438401,0.0001963567,0.0002297033,0.0001516745,0.0002654929,0.001452734],"category_scores_gemma":[0.0001295038,0.0001317143,0.0002730654,0.0001467822,0.0001385722,0.0002530835,0.0003035612,0.000543185,0.0007432604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003701393,"about_ca_system_score_gemma":0.0002810332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008159217,"about_ca_topic_score_gemma":0.001277983,"domain_scores_codex":[0.9998924,0.00002499618,0.000008720661,0.00001835322,0.00002846422,0.00002711634],"domain_scores_gemma":[0.9999076,0.00001795076,0.00002234549,0.00001405227,0.00002081149,0.00001723859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001899888,0.00002550127,0.0001234136,0.00009141202,0.000006607847,0.0001099982,0.00001789007,0.0000350778,0.9977901,0.0000728345,0.00006265962,0.001474478],"study_design_scores_gemma":[0.00003673458,0.000304891,0.003565108,0.00001152621,0.00001832001,0.0002969841,0.00003222851,0.0003473292,0.9918339,0.00009231119,0.003455743,0.000004865935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9710849,0.0156472,0.005747693,0.0005753624,0.0001444056,0.0001135183,0.0006782626,0.0002033953,0.00580531],"genre_scores_gemma":[0.9885693,0.005507734,0.001777367,0.0001110223,0.00003365228,0.00009803168,0.000496892,0.00001777176,0.003388172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001452734,"threshold_uncertainty_score":0.004859924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418342099374264,"score_gpt":0.2437765309151615,"score_spread":0.2295931099214188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}