{"id":"W2116103937","doi":"10.1093/carcin/bgi371","title":"Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells","year":2005,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bell (Canada)","funders":"","keywords":"Ceramide; Curcumin; Apoptosis; Sphingomyelin; Programmed cell death; Reactive oxygen species; Lipid signaling; Cell biology; Signal transduction; Acid sphingomyelinase; Chemistry; Sphingolipid; Cancer cell; Cell culture; Biology; Biochemistry; Cancer research; Cancer; Receptor; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002735783,0.0001333742,0.0001239671,0.0000390994,0.00008691567,0.00002293496,0.00017788,0.0001256623,0.00005513073],"category_scores_gemma":[0.00003207197,0.0001062845,0.00006821844,0.0001089055,0.00004223322,0.000004839841,0.00004715476,0.00006379675,0.000008528923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004064141,"about_ca_system_score_gemma":0.0001042994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002404221,"about_ca_topic_score_gemma":0.001019981,"domain_scores_codex":[0.9990846,0.00008950125,0.0001866103,0.0002570665,0.0001054974,0.0002767602],"domain_scores_gemma":[0.9995743,0.00001629989,0.00005450847,0.0002416368,0.00005108842,0.0000621665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001690204,0.00002067327,0.007029975,0.00000579671,0.00001226154,0.000002052205,0.0002759217,0.004741682,0.9765314,0.00001294761,0.0002533621,0.01109704],"study_design_scores_gemma":[0.0003347519,0.00001614212,0.004623074,0.000003743973,0.00001616861,0.000005192245,0.0000476473,0.002437197,0.9733468,0.000006345532,0.0190258,0.0001371885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883803,0.009445836,0.001336442,0.0003163118,0.0002692485,0.0001458954,0.00001490456,0.000008368726,0.00008274704],"genre_scores_gemma":[0.9958032,0.0006271892,0.0002924235,0.0009939851,0.001972435,0.00008930613,0.00004178042,0.00002297556,0.0001567228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01877243,"threshold_uncertainty_score":0.4334154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418342099374264,"score_gpt":0.2437765309151615,"score_spread":0.2295931099214188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}