{"id":"W2116116662","doi":"10.1523/jneurosci.0957-07.2007","title":"Defective Retrotranslocation Causes Loss of Anti-Bax Function in Human Familial Prion Protein Mutants","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; Case Western Reserve University; University of Washington","keywords":"Mutant; Fatal familial insomnia; Apoptosis; Cytosol; Cell biology; Programmed cell death; Biology; Wild type; Mutation; Molecular biology; Function (biology); Loss function; Prion protein; Phenotype; Gene; Biochemistry; Enzyme; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001528692,0.0002993694,0.0001838256,0.0001794337,0.0001397396,0.0002065063,0.0001822064,0.0002939857,0.0006564216],"category_scores_gemma":[0.0001389756,0.0001535819,0.0002604835,0.0001330985,0.0001880759,0.0001068595,0.0001435184,0.0003086292,0.0003337497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001622903,"about_ca_system_score_gemma":0.000122257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000464487,"about_ca_topic_score_gemma":0.0005465798,"domain_scores_codex":[0.9998488,0.00003779492,0.00002666053,0.00002477841,0.00004017616,0.00002165525],"domain_scores_gemma":[0.9998651,0.00003789536,0.00004141691,0.00001910787,0.000009676536,0.00002691908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001244435,0.00004401075,0.0002910313,0.00002008639,0.0000095275,0.0002184181,0.00001869257,0.00006508605,0.9985409,0.00008476622,0.00002162655,0.0005615057],"study_design_scores_gemma":[0.00005840201,0.0009371216,0.007766729,0.000007426612,0.00003772307,0.003295073,0.0000406699,0.001669591,0.9847831,0.00009117382,0.001305168,0.000007897893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988729,0.0002305668,0.0005184814,0.0000214931,0.000007927422,0.000009003565,0.0001038856,0.00002082468,0.0002148326],"genre_scores_gemma":[0.9983332,0.0002034266,0.000689725,0.00001636449,0.000004502086,0.00001053573,0.0002583782,0.00001052279,0.000473291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006564216,"threshold_uncertainty_score":0.002195954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01637167289265867,"score_gpt":0.2862168733875417,"score_spread":0.269845200494883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}