{"id":"W2116129679","doi":"10.1095/biolreprod.113.110924","title":"The ERK1/2 Signaling Pathway Regulates 11beta-Hydroxysteroid Dehydrogenase Type 2 Expression in Human Trophoblast Cells Through a Transcriptional Mechanism1","year":2013,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Birth, Development, and Health","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Trophoblast; Gene knockdown; Cell biology; Regulator; Signal transduction; Placenta; Transcriptional regulation; Regulation of gene expression; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Downregulation and upregulation; Gene expression; Gene; Fetus; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005394651,0.0001469099,0.0002875016,0.0000830437,0.0002029196,0.000007978929,0.00008523735,0.0001741661,0.0001173503],"category_scores_gemma":[0.00004384548,0.00009922164,0.00006544078,0.0001691898,0.0001510437,0.0000944832,0.00001893569,0.0002032064,0.00002950423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006154623,"about_ca_system_score_gemma":0.0001013108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001402223,"about_ca_topic_score_gemma":0.00002142369,"domain_scores_codex":[0.9984813,0.0001452498,0.0004895327,0.0004820107,0.000132047,0.0002698656],"domain_scores_gemma":[0.9991848,0.00002861431,0.0001973796,0.0003832198,0.0001518353,0.00005418164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001171529,0.00009952499,0.0005088884,0.00006945319,0.00002289476,0.000001388183,0.000573895,0.000009701677,0.9934989,0.002991031,0.0002293202,0.001877894],"study_design_scores_gemma":[0.0006568574,0.0004485826,0.002344032,0.00009874822,0.00001182394,0.00003146256,0.0002202193,0.0000253274,0.9724189,0.01966467,0.003981052,0.000098307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938161,0.003520852,0.0002059863,0.001076252,0.0005688681,0.0006125452,0.000002985621,0.00004211923,0.0001542904],"genre_scores_gemma":[0.9924316,0.004516982,0.002415589,0.00007867296,0.0002743986,0.0000486004,0.00005211241,0.00001722036,0.0001648533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02107994,"threshold_uncertainty_score":0.4046141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02942894894694634,"score_gpt":0.2721933507784933,"score_spread":0.2427644018315469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}