{"id":"W2116130249","doi":"10.1371/journal.pone.0095566","title":"Sphingosine 1-Phosphate (S1P) Induced Interleukin-8 (IL-8) Release Is Mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS-2B Cells","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Sphingosine-1-phosphate; Sphingosine-1-phosphate receptor; Sphingosine; Receptor; Sphingosine kinase; S1PR1; Chemokine; Cell biology; Respiratory epithelium; Cytokine; Chemistry; Biology; Immunology; Cancer research; Epithelium; Biochemistry; Vascular endothelial growth factor; Vascular endothelial growth factor A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002225313,0.0003644332,0.0003465902,0.0003135722,0.0002735967,0.0004175424,0.0002224227,0.0004214778,0.002044179],"category_scores_gemma":[0.0001135023,0.0003059049,0.0005930145,0.0002853889,0.0002356035,0.0004392189,0.0001947433,0.0009427435,0.0009135655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003395565,"about_ca_system_score_gemma":0.0002256232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000916353,"about_ca_topic_score_gemma":0.000904364,"domain_scores_codex":[0.9997438,0.00004746493,0.00002350531,0.00004200262,0.00008709281,0.00005621279],"domain_scores_gemma":[0.9999328,0.000007703551,0.00001816967,0.00001310443,0.00001008515,0.00001814894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001615777,0.00003335908,0.000131425,0.00002208988,0.000004175455,0.00007382271,0.00001499439,0.00003779113,0.9989396,0.000106853,0.00003141115,0.0004429927],"study_design_scores_gemma":[0.0001229896,0.0007118849,0.01897801,0.00001618824,0.00003158791,0.001008631,0.0001554107,0.003132395,0.9681428,0.0003496831,0.007331351,0.00001899939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858676,0.004833513,0.00601574,0.000595236,0.00009453384,0.00004239079,0.0008477657,0.0001218449,0.001581446],"genre_scores_gemma":[0.9901238,0.002275393,0.002411522,0.00007280737,0.00002481428,0.00008030594,0.000833125,0.0000175283,0.004160716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002044179,"threshold_uncertainty_score":0.006838441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01434650866816547,"score_gpt":0.1985921400571322,"score_spread":0.1842456313889668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}