{"id":"W2116130249","doi":"10.1371/journal.pone.0095566","title":"Sphingosine 1-Phosphate (S1P) Induced Interleukin-8 (IL-8) Release Is Mediated by S1P Receptor 2 and Nuclear Factor κB in BEAS-2B Cells","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Sphingosine-1-phosphate; Sphingosine-1-phosphate receptor; Sphingosine; Receptor; Sphingosine kinase; S1PR1; Chemokine; Cell biology; Respiratory epithelium; Cytokine; Chemistry; Biology; Immunology; Cancer research; Epithelium; Biochemistry; Vascular endothelial growth factor; Vascular endothelial growth factor A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002231955,0.0002634973,0.0003734495,0.0000738558,0.0000696057,0.00005696323,0.0002337962,0.0002663444,0.0001791022],"category_scores_gemma":[0.0003055591,0.0002631327,0.00005955101,0.0001332656,0.00006071482,0.00001403252,0.0001526558,0.0002348019,0.00006913339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001772829,"about_ca_system_score_gemma":0.00002643523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000142319,"about_ca_topic_score_gemma":0.00001687154,"domain_scores_codex":[0.9983856,0.00008974751,0.0003761509,0.0005372668,0.0002297261,0.0003815108],"domain_scores_gemma":[0.9991481,0.00003450659,0.0001452811,0.0003707776,0.00007837535,0.0002229056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001357328,0.0003308933,0.001180528,0.00005621505,0.00009470017,0.000001258088,0.0003619688,4.234033e-7,0.9954252,0.00001172985,0.00153941,0.0008618994],"study_design_scores_gemma":[0.001356983,0.0002272134,0.0004759817,0.00009516669,0.00004918489,9.3324e-7,0.00005799254,0.0002978489,0.9770249,0.00001253163,0.02006763,0.0003336899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980649,0.0009248557,0.00002561786,0.0003166415,0.0001252357,0.0002256209,0.0001180928,0.00003453029,0.0001645566],"genre_scores_gemma":[0.9964116,0.000794902,0.0006457562,0.001353459,0.0003107757,0.00001334355,0.000161504,0.00006623497,0.0002424429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01852822,"threshold_uncertainty_score":0.9999821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01434650866816547,"score_gpt":0.1985921400571322,"score_spread":0.1842456313889668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}