{"id":"W2116149498","doi":"10.1128/aac.48.10.3954-3958.2004","title":"Mutant Prevention Concentrations for Single-Step Fluoroquinolone-Resistant Mutants of Wild-Type, Efflux-Positive, or ParC or GyrA Mutation-Containing <i>Streptococcus pneumoniae</i> Isolates","year":2004,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Health Sciences Centre","funders":"","keywords":"Gatifloxacin; Moxifloxacin; Levofloxacin; Gemifloxacin; Efflux; Microbiology; Ciprofloxacin; Mutant; Streptococcus pneumoniae; Biology; Antibacterial agent; Quinolone; Sparfloxacin; Minimum inhibitory concentration; DNA gyrase; Ofloxacin; Antibiotics; Escherichia coli; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002669725,0.0004257839,0.0003981836,0.0002902798,0.0001291471,0.0003307551,0.0003001344,0.0004992175,0.001418783],"category_scores_gemma":[0.0009978528,0.0002572241,0.0002543358,0.0001948581,0.0001833617,0.0002196826,0.0001730278,0.0004520264,0.0002488949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003228964,"about_ca_system_score_gemma":0.0002300478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001579345,"about_ca_topic_score_gemma":0.001309172,"domain_scores_codex":[0.9995223,0.0001145616,0.00007720881,0.00008066204,0.0001326628,0.00007260473],"domain_scores_gemma":[0.9990915,0.0003085296,0.0002137275,0.000109405,0.0001458287,0.0001310221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008891159,0.0001491342,0.003996709,0.00005196832,0.00002052782,0.00005407128,0.00005749023,0.0005587182,0.9915062,0.00006985689,0.0001107907,0.002535496],"study_design_scores_gemma":[0.00003697578,0.004352728,0.02960558,0.00001144546,0.00005157393,0.0002964692,0.0001002956,0.001887309,0.9628061,0.00005320629,0.0007780836,0.00002018952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998735,0.0001767424,0.000383557,0.0000273015,0.00000991724,0.00001506947,0.000264236,0.00002707948,0.0003611442],"genre_scores_gemma":[0.9972045,0.0001277764,0.001121406,0.00002043333,0.00000723942,0.00002588929,0.0007204859,0.0000144106,0.0007578437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001579345,"threshold_uncertainty_score":0.004746258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02725306926202051,"score_gpt":0.2952939183410836,"score_spread":0.2680408490790631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}