{"id":"W2116152202","doi":"10.1517/13543784.11.7.991","title":"Bosentan: a dual endothelin receptor antagonist","year":2002,"lang":"en","type":"review","venue":"Expert Opinion on Investigational Drugs","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Bosentan; Endothelin receptor antagonist; Medicine; Endothelin receptor; Pulmonary hypertension; Tolerability; Internal medicine; Cardiology; Pharmacology; Receptor; Adverse effect","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001828921,0.0006771828,0.001520782,0.0004633837,0.0002698973,0.000060741,0.00020501,0.0004075081,0.002230538],"category_scores_gemma":[0.000298418,0.0005012311,0.0006741532,0.0004182345,0.0003349482,0.0001037624,0.00009688393,0.000722051,0.006828274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000443508,"about_ca_system_score_gemma":0.000864711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002652132,"about_ca_topic_score_gemma":1.485629e-7,"domain_scores_codex":[0.9961541,0.0002951864,0.0008005932,0.0008615782,0.001358054,0.0005304908],"domain_scores_gemma":[0.9976538,0.0004218348,0.0002676068,0.0006233308,0.0001593796,0.0008739791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001098406,0.001330059,0.00001275686,0.00218221,0.0006978691,0.0005282109,0.0001139309,2.227947e-7,0.00002241815,0.003010219,0.3766941,0.6152982],"study_design_scores_gemma":[0.001083197,0.0003762508,0.000005578653,0.01039347,0.00004030015,0.0006170204,0.00002646226,0.00002940592,0.0000331109,0.00009970864,0.9869014,0.0003940983],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000006076019,0.9867821,0.000001093866,0.003153767,0.001016755,0.001319403,0.0005939015,0.0001326387,0.006994242],"genre_scores_gemma":[0.000005859024,0.9773212,0.001037037,0.002248589,0.001736427,0.0005687647,0.005806365,0.0001190924,0.01115666],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.614904,"threshold_uncertainty_score":0.9997439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.109545352175218,"score_gpt":0.3838684803300484,"score_spread":0.2743231281548305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}