{"id":"W2116158024","doi":"10.1093/hmg/ddp551","title":"Effects of dyskeratosis congenita mutations in dyskerin, NHP2 and NOP10 on assembly of H/ACA pre-RNPs","year":2009,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Canadian Institutes of Health Research; University of Washington","keywords":"Dyskeratosis congenita; Telomere; Biology; Telomerase; Mutation; Small nucleolar RNA; Ribonucleoprotein; RNA; Telomerase RNA component; Genetics; Molecular biology; Gene; Telomerase reverse transcriptase; Cancer research; Long non-coding RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603856,0.0005700046,0.0002251025,0.0003332556,0.0001506715,0.0001796562,0.0002076353,0.0004485101,0.002334396],"category_scores_gemma":[0.000259643,0.0001884697,0.0002693197,0.0001097733,0.0002873758,0.0001307376,0.0002277191,0.0003998011,0.000331404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002293094,"about_ca_system_score_gemma":0.0001356933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001369211,"about_ca_topic_score_gemma":0.001655111,"domain_scores_codex":[0.9997581,0.00006105088,0.00003631053,0.00005914411,0.00004573433,0.0000395966],"domain_scores_gemma":[0.9995899,0.0001403792,0.00007151898,0.00003398527,0.00002312595,0.0001411362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008768871,0.0002211588,0.001355801,0.00004254522,0.00002774057,0.0007206682,0.00002486454,0.0001690591,0.9950554,0.00006078226,0.00007242599,0.001372654],"study_design_scores_gemma":[0.0001458376,0.002544111,0.05785572,0.00001738885,0.00009633623,0.002561859,0.00009054579,0.002540726,0.9318726,0.00009509917,0.002160938,0.00001890453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983505,0.0003007176,0.0001443862,0.00003012266,0.00001579396,0.00001227879,0.0001475382,0.00002952934,0.0009691313],"genre_scores_gemma":[0.9982914,0.000158279,0.0002456763,0.00003191023,0.000005755704,0.00001411984,0.0001687362,0.00002207913,0.00106211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002334396,"threshold_uncertainty_score":0.007809281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008460677550671394,"score_gpt":0.2745776050607484,"score_spread":0.266116927510077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}