{"id":"W2116161233","doi":"10.1016/j.jconrel.2011.12.036","title":"Targeting the amyloid-β antibody in the brain tissue of a mouse model of Alzheimer's disease","year":2011,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Medical Research Council; Wellcome Trust","keywords":"Monoclonal antibody; Antibody; Pathology; Alzheimer's disease; In vivo; Chemistry; Extracellular; Parenchyma; Neuroscience; Disease; Biology; Immunology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004962265,0.0009235638,0.0007081304,0.0009999779,0.0003430134,0.0005682671,0.0005601681,0.001127809,0.0007790976],"category_scores_gemma":[0.0001981942,0.0004415239,0.0006858106,0.0002843344,0.0005646247,0.0006740868,0.0001669142,0.001882182,0.0003465966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004523333,"about_ca_system_score_gemma":0.0003677639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001382929,"about_ca_topic_score_gemma":0.001483003,"domain_scores_codex":[0.9997415,0.00003040029,0.00002617512,0.00006914381,0.00005533341,0.00007742115],"domain_scores_gemma":[0.9997444,0.00003542445,0.00007055524,0.00003218262,0.00004390976,0.00007365039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006273044,0.0001728605,0.00006623458,0.0000471882,0.00001508086,0.0001152611,0.00002771978,0.00007323828,0.9976121,0.0001502157,0.00007810954,0.001014612],"study_design_scores_gemma":[0.0001732129,0.002343056,0.001434856,0.00001795937,0.0001169858,0.0006478241,0.00004044914,0.001229774,0.9921347,0.0001875187,0.00166029,0.00001331635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896074,0.002513296,0.005396496,0.0003503891,0.0001562825,0.00008789032,0.0004184815,0.0002214205,0.001248224],"genre_scores_gemma":[0.9827168,0.003049117,0.00616146,0.0001820116,0.00006156866,0.000171494,0.0005411158,0.00007735354,0.007038961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382929,"threshold_uncertainty_score":0.003281951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03375828241369162,"score_gpt":0.328961703781571,"score_spread":0.2952034213678794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}