{"id":"W2116162205","doi":"10.1186/1475-2840-13-24","title":"Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK","year":2014,"lang":"en","type":"article","venue":"Cardiovascular Diabetology","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China; National Science Foundation","keywords":"Rosiglitazone; Internal medicine; Endocrinology; Glucokinase; Insulin resistance; Knockout mouse; Medicine; Diabetic cardiomyopathy; Protein kinase B; AMPK; Insulin; Insulin receptor; Western blot; Receptor; Biology; Phosphorylation; Protein kinase A; Cardiomyopathy; Heart failure; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002003887,0.0006679559,0.002177956,0.0003693766,0.0004039078,0.0001042819,0.0001493514,0.0006162192,0.0000633513],"category_scores_gemma":[0.0005972412,0.0006219582,0.001806584,0.0004813713,0.0004503512,0.0001798226,0.0002639534,0.0006674876,0.00003680645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000176939,"about_ca_system_score_gemma":0.00006485903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009608061,"about_ca_topic_score_gemma":0.000005633356,"domain_scores_codex":[0.9952403,0.001049754,0.000691545,0.001433364,0.0006910916,0.0008938994],"domain_scores_gemma":[0.9970917,0.0002808711,0.0001922414,0.001567182,0.0002371134,0.0006309591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0002571825,0.0001098217,0.2951505,0.0006869825,0.007549795,0.0001494865,0.0007383258,0.00006137359,0.09998459,0.00008120025,0.0008876464,0.5943431],"study_design_scores_gemma":[0.01555002,0.0006086447,0.8292768,0.0004579526,0.004930304,0.002750236,0.0002599971,0.000527335,0.0985178,0.00004711108,0.04519097,0.001882813],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9464083,0.04872686,0.00236681,0.00008554718,0.0010523,0.0008987721,0.00002515605,0.0002191979,0.0002170847],"genre_scores_gemma":[0.9948193,0.003012658,0.0006786718,0.0001655396,0.0007716715,0.00008181308,0.0002340566,0.0001360696,0.0001001852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5924603,"threshold_uncertainty_score":0.9996232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01168450472493391,"score_gpt":0.2108551757684003,"score_spread":0.1991706710434664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}