{"id":"W2116190612","doi":"10.1016/j.devcel.2010.08.007","title":"Extended-Synaptotagmin-2 Mediates FGF Receptor Endocytosis and ERK Activation In Vivo","year":2010,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Cancer Institute; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Canadian Cancer Society; Eli Lilly and Company","keywords":"Cell biology; Biology; Endocytic cycle; Endocytosis; Clathrin; Fibroblast growth factor; MAPK/ERK pathway; Signal transduction; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001018302,0.0001209339,0.00008771551,0.00005071756,0.00004790225,0.00001438541,0.00007024012,0.0001401897,0.0002528608],"category_scores_gemma":[0.00001289292,0.0001230499,0.00002559577,0.00006331054,0.00004526986,0.000006992378,0.00003408414,0.0001140806,0.00001308695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001349085,"about_ca_system_score_gemma":0.00004637774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002585146,"about_ca_topic_score_gemma":0.0001857534,"domain_scores_codex":[0.9993218,0.0000128224,0.0001546323,0.0002576951,0.00008924271,0.000163854],"domain_scores_gemma":[0.9997908,0.000007815818,0.00003889881,0.00008209174,0.00001844551,0.00006194312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004209658,0.00004512383,0.02028423,0.00001252662,0.000006241265,0.000001284298,0.0001686552,2.007983e-7,0.9781498,0.00001415046,0.0001072008,0.001168529],"study_design_scores_gemma":[0.0004364551,0.00003608355,0.02350275,0.000005297313,0.000003006063,0.000003880637,0.0001377109,0.000005889747,0.9294496,0.00001950083,0.04624071,0.0001591639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969518,0.00006194549,0.0002406785,0.00004657903,0.0001532411,0.0001259131,0.000007370915,0.000009661978,0.002402829],"genre_scores_gemma":[0.9956815,0.0001434648,0.002427557,0.00007930057,0.00006807772,0.00002046175,0.0009863494,0.00001495701,0.0005783623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04870021,"threshold_uncertainty_score":0.501783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004903226147245905,"score_gpt":0.1937472582410038,"score_spread":0.1888440320937579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}