{"id":"W2116190612","doi":"10.1016/j.devcel.2010.08.007","title":"Extended-Synaptotagmin-2 Mediates FGF Receptor Endocytosis and ERK Activation In Vivo","year":2010,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Cancer Institute; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Canadian Cancer Society; Eli Lilly and Company","keywords":"Cell biology; Biology; Endocytic cycle; Endocytosis; Clathrin; Fibroblast growth factor; MAPK/ERK pathway; Signal transduction; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005782229,0.0005848979,0.00039091,0.0004079727,0.0003213281,0.000807454,0.00063179,0.0006943598,0.001888521],"category_scores_gemma":[0.0003232321,0.0004465699,0.0005648138,0.0002186968,0.000468335,0.0008961175,0.0007743613,0.001661063,0.0008649473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001181067,"about_ca_system_score_gemma":0.0004827685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001704326,"about_ca_topic_score_gemma":0.003957285,"domain_scores_codex":[0.9996189,0.00006072252,0.00003184782,0.00008984175,0.00009036204,0.0001083541],"domain_scores_gemma":[0.9997639,0.00006234686,0.00003839669,0.00004810708,0.00002613746,0.00006114744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002597123,0.00001771387,0.00008172319,0.00002379249,0.000008655978,0.00004447053,0.00001678517,0.00004107654,0.9988273,0.00024608,0.00004006061,0.0003925782],"study_design_scores_gemma":[0.00006242358,0.00006805819,0.003057908,0.000005435771,0.0000169733,0.0002534528,0.00003274183,0.001529853,0.9932156,0.0001076861,0.001641229,0.000008641447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883486,0.001829608,0.0067467,0.0002793557,0.00006813848,0.00003619211,0.0005263895,0.00009551705,0.002069521],"genre_scores_gemma":[0.9852052,0.0006901246,0.005032492,0.0001241831,0.00002551725,0.00006806078,0.001299357,0.0001185267,0.007436491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888521,"threshold_uncertainty_score":0.0085693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004903226147245905,"score_gpt":0.1937472582410038,"score_spread":0.1888440320937579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}