{"id":"W2116195267","doi":"10.2337/diabetes.51.7.2090","title":"Sustained Exposure of L6 Myotubes to High Glucose and Insulin Decreases Insulin-Stimulated GLUT4 Translocation but Upregulates GLUT4 Activity","year":2002,"lang":"en","type":"article","venue":"Diabetes","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Diabetes Association","keywords":"GLUT4; Glucose uptake; Internal medicine; Insulin resistance; Glucose transporter; Endocrinology; Insulin; Insulin receptor; Biology; Protein kinase B; IRS1; Phosphorylation; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001652851,0.0004351705,0.0004298114,0.0001536538,0.0002257049,0.0002943818,0.0002555938,0.0002520612,0.001778164],"category_scores_gemma":[0.00006540523,0.0001493907,0.0003771769,0.0002631977,0.0002530724,0.0002070396,0.0002705021,0.0006541166,0.000549126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003735646,"about_ca_system_score_gemma":0.00029899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009646542,"about_ca_topic_score_gemma":0.002122744,"domain_scores_codex":[0.9997838,0.0000369945,0.00002532706,0.0000519856,0.00004480144,0.00005703107],"domain_scores_gemma":[0.9999254,0.0000102485,0.0000164178,0.0000124478,0.000009551526,0.00002588601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002884735,0.0000550575,0.0001573045,0.00004254347,0.000005669704,0.00003902497,0.00001237573,0.00001518799,0.9986489,0.00002223633,0.00003586725,0.0006772673],"study_design_scores_gemma":[0.00005229952,0.001036825,0.007812304,0.000008172132,0.0000196026,0.0001426719,0.00004919316,0.0003510027,0.9887232,0.00002447653,0.001775507,0.00000476759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933805,0.00265869,0.001700823,0.0001912338,0.00007787426,0.00003670894,0.0004629205,0.00007136726,0.001419795],"genre_scores_gemma":[0.9896896,0.002013418,0.0032762,0.0001396631,0.00003294483,0.0001160485,0.001221945,0.00003495549,0.003475375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001778164,"threshold_uncertainty_score":0.005948544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007921527483204667,"score_gpt":0.2124186689300854,"score_spread":0.2044971414468807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}