{"id":"W2116199022","doi":"10.1016/j.ijrobp.2014.05.140","title":"The Significance of p16 and p53 Expression on Clinical Outcome in Patients with Anal Cancer Treated with Chemoradiation Therapy: An Analysis of RTOG 98-11","year":2014,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Colorectal and Anal Carcinomas","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Juravinski Cancer Centre; University of Calgary","funders":"","keywords":"Medicine; Immunohistochemistry; Anal cancer; Oncology; Internal medicine; Surrogate endpoint; Clinical significance; Proportional hazards model; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002834815,0.0001911213,0.0003999496,0.0006635759,0.000284055,0.0004731967,0.0002592057,0.0003166439,0.0009872885],"category_scores_gemma":[0.0009233869,0.0001496822,0.0004247273,0.0008161184,0.0002520499,0.0002932677,0.0003123664,0.0003298633,0.0002106305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002743686,"about_ca_system_score_gemma":0.0002241726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00151568,"about_ca_topic_score_gemma":0.001900915,"domain_scores_codex":[0.9997776,0.00005990989,0.00002308563,0.00004534034,0.00003688584,0.00005715955],"domain_scores_gemma":[0.9993273,0.0001913415,0.0002465411,0.000043579,0.00005716263,0.0001340107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001129786,0.00007058877,0.9957994,0.000006653444,0.00006837249,0.00008913228,0.00004464303,0.00005996661,0.001055025,0.000008061963,0.00003560343,0.001632733],"study_design_scores_gemma":[0.00001475813,0.0003413492,0.9989744,0.000001456985,0.00004683424,0.0002091562,0.00008543302,0.00009920682,0.0001119313,0.000009476494,0.0001038121,0.000002142871],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995698,0.0001179846,0.00001819791,0.00001123139,0.000001581987,0.000002248691,0.00009072743,0.000001206239,0.0001870424],"genre_scores_gemma":[0.9996325,0.00004540627,0.0000161938,0.000008564193,0.000004143325,0.000002697417,0.0001858133,0.000001877866,0.0001028712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00151568,"threshold_uncertainty_score":0.003302813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02844524338331532,"score_gpt":0.3527910785456498,"score_spread":0.3243458351623345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}