{"id":"W2116232221","doi":"10.1084/jem.20070583","title":"Chromosomal reinsertion of broken RSS ends during T cell development","year":2007,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Leukemia and Lymphoma Society; Genome Canada; Ontario Genomics; Ontario Genomics Institute","keywords":"Recombinase; Recombination signal sequences; Biology; RAG2; Recombination-activating gene; Genetics; V(D)J recombination; Molecular biology; DNA; Chromosomal translocation; Mutant; Thymocyte; Cell biology; Recombination; Antigen; Gene; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002272168,0.0002339481,0.0001644688,0.0002697334,0.0001376881,0.000397494,0.0001813823,0.0002907571,0.0004614131],"category_scores_gemma":[0.0003862587,0.000195934,0.0001380406,0.0001707107,0.0002588286,0.0002365419,0.0002691744,0.0004046338,0.0003000938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002289297,"about_ca_system_score_gemma":0.0001180141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002524853,"about_ca_topic_score_gemma":0.0004767008,"domain_scores_codex":[0.9997202,0.0000633005,0.00002431157,0.00006285127,0.00007924244,0.00005015439],"domain_scores_gemma":[0.9997141,0.00007675034,0.00008336377,0.00005328259,0.00002697538,0.00004556728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001100533,0.00001118011,0.001224182,0.00001239509,0.000003187193,0.0001112088,0.00001855641,0.000075343,0.996744,0.00007400986,0.000007760105,0.001608062],"study_design_scores_gemma":[0.000005208621,0.0001845415,0.007332659,0.000002885161,0.000009751097,0.0006243289,0.00002448351,0.0005753406,0.9904237,0.00004030563,0.0007735976,0.000003161799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997122,0.0004768141,0.001986817,0.0000108765,0.000004379669,0.000005329312,0.00005419468,0.00003227676,0.0003072846],"genre_scores_gemma":[0.997916,0.0002084812,0.00123503,0.00001029671,0.00000247225,0.000003761848,0.0001649835,0.00001261382,0.0004461662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004614131,"threshold_uncertainty_score":0.001661003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008700310025599026,"score_gpt":0.2590577623912236,"score_spread":0.2503574523656246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}