{"id":"W2116233222","doi":"10.1158/0008-5472.can-07-1938","title":"Pediatric <i>KIT</i> –Wild-Type and Platelet-Derived Growth Factor Receptor α–Wild-Type Gastrointestinal Stromal Tumors Share KIT Activation but not Mechanisms of Genetic Progression with Adult Gastrointestinal Stromal Tumors","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"PDGFRA; GiST; Cancer research; Growth factor receptor; Biology; Stromal tumor; Proto-Oncogene Proteins c-kit; Malignancy; Stromal cell; Wild type; Cancer; Pathology; Medicine; Mutant; Stem cell factor; Genetics; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008379443,0.0006766672,0.000846695,0.0008926499,0.0004046065,0.0001161205,0.0004378551,0.00009431194,0.0004273038],"category_scores_gemma":[0.001999751,0.0005331439,0.0001258237,0.00177867,0.0006322495,0.0002894408,0.0003251808,0.001616506,0.00004061888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007387939,"about_ca_system_score_gemma":0.001984708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008656984,"about_ca_topic_score_gemma":0.00008390997,"domain_scores_codex":[0.9927011,0.0002810393,0.0008839497,0.001216292,0.002793293,0.002124286],"domain_scores_gemma":[0.9929805,0.0005054759,0.0004235379,0.0005701665,0.004126024,0.001394264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01525876,0.0006128161,0.3918674,0.0008249439,0.00006808044,0.001920055,0.00009078841,0.0000128963,0.5873989,0.0001138098,0.000215811,0.001615766],"study_design_scores_gemma":[0.005410787,0.03128222,0.5590824,0.003960058,0.0000877565,0.005161721,0.0007627216,0.0001457588,0.3935782,0.00007368918,0.000008147998,0.0004465296],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955162,0.0001541007,0.001330077,0.0004628223,0.00005181372,0.002121551,0.0001459572,0.0001333815,0.00008404382],"genre_scores_gemma":[0.9589566,0.00006415051,0.03988907,0.00004193897,0.0004511898,0.0001347238,0.0001562534,0.0001423188,0.0001637684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1938206,"threshold_uncertainty_score":0.999712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04092622421768243,"score_gpt":0.3365817876281816,"score_spread":0.2956555634104992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}