{"id":"W2116233222","doi":"10.1158/0008-5472.can-07-1938","title":"Pediatric <i>KIT</i> –Wild-Type and Platelet-Derived Growth Factor Receptor α–Wild-Type Gastrointestinal Stromal Tumors Share KIT Activation but not Mechanisms of Genetic Progression with Adult Gastrointestinal Stromal Tumors","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"PDGFRA; GiST; Cancer research; Growth factor receptor; Biology; Stromal tumor; Proto-Oncogene Proteins c-kit; Malignancy; Stromal cell; Wild type; Cancer; Pathology; Medicine; Mutant; Stem cell factor; Genetics; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416654,0.0003106718,0.0002377801,0.0004388571,0.0001361987,0.0003090565,0.000130198,0.0001490082,0.00107962],"category_scores_gemma":[0.0004058114,0.0001819485,0.0002035197,0.0005075316,0.0003209946,0.0002915768,0.0002148359,0.0003417991,0.00037213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002447223,"about_ca_system_score_gemma":0.0002837992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006668783,"about_ca_topic_score_gemma":0.0006133567,"domain_scores_codex":[0.9998422,0.00001581672,0.00001870149,0.00003873476,0.00004525509,0.00003925652],"domain_scores_gemma":[0.9995756,0.00004001904,0.0002376398,0.00003544768,0.00004232468,0.00006907803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000617235,0.0000741904,0.6950223,0.000154535,0.00009880913,0.01249449,0.0003233101,0.0006329748,0.2203488,0.001258913,0.0007780769,0.06819645],"study_design_scores_gemma":[0.00003724908,0.0005995534,0.7957628,0.00001855769,0.00007313842,0.1438483,0.0003282393,0.0006143365,0.04797337,0.0005511075,0.01018062,0.00001276755],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932649,0.00148162,0.002100183,0.00006368666,0.000006562759,0.00002366433,0.0002660021,0.00005460588,0.002738739],"genre_scores_gemma":[0.9969851,0.0009541149,0.001168934,0.00003037606,0.00001090792,0.00001377872,0.000533586,0.00001118548,0.0002919106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00107962,"threshold_uncertainty_score":0.003611684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04092622421768243,"score_gpt":0.3365817876281816,"score_spread":0.2956555634104992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}