{"id":"W2116247944","doi":"10.1074/jbc.m411521200","title":"Cannabinoid Receptor-induced Neurite Outgrowth Is Mediated by Rap1 Activation through Gαo/i-triggered Proteasomal Degradation of Rap1GAPII","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Institutes of Health; York University","keywords":"Neurite; Rap1; Cannabinoid receptor; Cell biology; Degradation (telecommunications); Chemistry; Cannabinoid; Receptor; Neuroscience; Biophysics; Signal transduction; Biochemistry; Biology; Antagonist; Computer science; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007519283,0.0005041144,0.0002499107,0.0002277803,0.0002482987,0.0002478295,0.0001673686,0.0001671311,0.0008552835],"category_scores_gemma":[0.00005755838,0.0001626151,0.0004589851,0.0001972322,0.000170497,0.0001550705,0.0001951848,0.0005051437,0.0004384178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007189922,"about_ca_system_score_gemma":0.0003719536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002468266,"about_ca_topic_score_gemma":0.003646141,"domain_scores_codex":[0.9999138,0.000006470366,0.000007405044,0.00001663474,0.00002204338,0.00003359022],"domain_scores_gemma":[0.9999555,0.000003998238,0.00001409506,0.000005401507,0.000004964887,0.00001595877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001040115,0.00001502674,0.00008233795,0.00003690932,0.000007429167,0.0000715907,0.000008534136,0.00004228983,0.9988219,0.00005784773,0.000045424,0.000706676],"study_design_scores_gemma":[0.00002006828,0.000144306,0.01060464,0.00001291208,0.0000201794,0.0003502603,0.00003159346,0.0007025849,0.9860693,0.00007481599,0.001962965,0.000006228066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918212,0.003526278,0.001078739,0.0001223136,0.00002843919,0.00002232978,0.0006292319,0.00008259832,0.002688834],"genre_scores_gemma":[0.9865855,0.004335599,0.002691167,0.0001033526,0.00001275095,0.00006713647,0.001500639,0.00002381317,0.00468011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002468266,"threshold_uncertainty_score":0.005216718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02491367462037066,"score_gpt":0.2564430031730612,"score_spread":0.2315293285526905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}