{"id":"W2116248687","doi":"10.1001/archpsyc.59.5.409","title":"Probing Brain Reward System Function in Major Depressive Disorder","year":2002,"lang":"en","type":"article","venue":"Archives of General Psychiatry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Dextroamphetamine; Psychology; Placebo; Major depressive disorder; Euphoriant; Depression (economics); Dopamine; Psychiatry; Mood; Anesthesia; Internal medicine; Medicine; Amphetamine; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004678301,0.0002172167,0.000365537,0.0001726015,0.00009595956,0.0001479335,0.000116725,0.0001900886,0.0005327419],"category_scores_gemma":[0.0006940719,0.00009439274,0.0001774381,0.0001262732,0.0001396028,0.00007082381,0.000114256,0.0002750776,0.00007639776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177789,"about_ca_system_score_gemma":0.0001190694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003722887,"about_ca_topic_score_gemma":0.0009180686,"domain_scores_codex":[0.9998203,0.00008313348,0.00002065848,0.00002211885,0.00003429214,0.00001955896],"domain_scores_gemma":[0.9997049,0.00007294818,0.0001182897,0.000009477275,0.00002830498,0.00006589622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02424698,0.002945044,0.8093291,0.0007321129,0.0007734659,0.000456986,0.0002577488,0.0008063582,0.08326492,0.00009425466,0.0006948694,0.07639815],"study_design_scores_gemma":[0.0006004686,0.0113187,0.984591,0.00001601165,0.0001334837,0.0004157103,0.00003791796,0.000373054,0.002124272,0.00004320122,0.0003409484,0.000005207502],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986841,0.0008235938,0.00008505939,0.00004502833,0.00000823278,0.00003972702,0.00008014524,0.000002686305,0.000231397],"genre_scores_gemma":[0.9991079,0.0003948349,0.0002154792,0.00006324188,0.00001208014,0.00002544137,0.0001082171,3.672747e-7,0.00007238013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005327419,"threshold_uncertainty_score":0.002474189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0196895179656537,"score_gpt":0.2524661112668856,"score_spread":0.2327765933012318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}