{"id":"W2116267379","doi":"10.1007/978-1-4939-2432-5_4","title":"Gene Therapy Strategies to Block HIV-1 Replication by RNA Interference","year":2015,"lang":"en","type":"review","venue":"Advances in experimental medicine and biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Ministerio de Economía y Competitividad; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Research Foundation; Deutsche Forschungsgemeinschaft; Medical Research Council; South African Medical Research Council; Poliomyelitis Research Foundation; McGill University","keywords":"RNA interference; Biology; RNA; Viral replication; Computational biology; Gene; Virology; Small hairpin RNA; Human immunodeficiency virus (HIV); Genetic enhancement; Lentivirus; RNA silencing; Genome; Virus; Genetics; Viral disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000428842,0.0008683582,0.001187295,0.001253645,0.0002317176,0.0006669458,0.0008682784,0.0007570015,0.001661267],"category_scores_gemma":[0.0003846482,0.0002761795,0.0003908959,0.0009484943,0.0005117018,0.00065061,0.0004810347,0.001756501,0.0009021732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005627185,"about_ca_system_score_gemma":0.0004985732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006016275,"about_ca_topic_score_gemma":0.001199552,"domain_scores_codex":[0.999871,0.00001581039,0.00001286769,0.0000217151,0.00005954438,0.00001897348],"domain_scores_gemma":[0.9998903,0.00005768192,0.0000187924,0.000004500911,0.00001936007,0.00000931653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008456682,0.0001144545,0.0001226504,0.01069266,0.00008769707,0.0002644474,0.00005728761,0.0007825689,0.0207868,0.008402351,0.01674316,0.9418615],"study_design_scores_gemma":[0.00004290937,0.0001539688,0.0005353219,0.001291195,0.000159668,0.001360496,0.00004073238,0.0004393349,0.009912726,0.003207464,0.9828248,0.00003139179],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003782477,0.9962717,0.001110444,0.0002116855,0.000270052,0.00001216167,0.00002022169,0.00002378479,0.0017017],"genre_scores_gemma":[0.003015402,0.99442,0.0009368488,0.0002338723,0.0001393244,0.0000214763,0.00004408021,0.000004099109,0.001184926],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001661267,"threshold_uncertainty_score":0.005557477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06433213525755088,"score_gpt":0.4204251155688144,"score_spread":0.3560929803112635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}