{"id":"W2116294468","doi":"10.1186/1742-4690-10-25","title":"The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import","year":2013,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Darwin Trust of Edinburgh; Canada Research Chairs","keywords":"Cypa; Cyclophilin A; Capsid; Mutant; Biology; Viral replication; Virology; Cyclophilin; Retrovirus; HEK 293 cells; Genetics; Molecular biology; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000256394,0.00009056447,0.0002066695,0.0001087205,0.00007589879,0.000005088797,0.00009161021,0.0001340053,0.0001135203],"category_scores_gemma":[0.000098884,0.00007005141,0.00002666151,0.00009087964,0.0001944805,0.00005333279,0.00003910661,0.0001365753,0.0001281028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008071219,"about_ca_system_score_gemma":0.00004136496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000617174,"about_ca_topic_score_gemma":0.0002123512,"domain_scores_codex":[0.9989641,0.0001775616,0.0003624819,0.00020024,0.00005634349,0.0002392926],"domain_scores_gemma":[0.9994609,0.0001337379,0.0001480187,0.0001707155,0.00006134187,0.000025273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007832474,0.0001519301,0.01149239,0.00001891753,0.00008448806,0.000003702441,0.0004320887,0.000007731102,0.9785002,0.001141724,0.004218709,0.00316483],"study_design_scores_gemma":[0.01014532,0.006439427,0.3817544,0.00006660153,0.00008329455,0.00003405666,0.001821224,0.00004303078,0.5737929,0.002320741,0.02311056,0.0003884309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99691,0.0009589195,0.00006654582,0.001043306,0.00007667279,0.0004975169,0.000044112,0.000007388006,0.0003955914],"genre_scores_gemma":[0.99824,0.0005757544,0.00004607466,0.00003553722,0.000005148574,0.00006172286,0.0001125338,0.000006802742,0.0009164198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4047073,"threshold_uncertainty_score":0.2856613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004523407131822424,"score_gpt":0.22493576551631,"score_spread":0.2204123583844876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}