{"id":"W2116294468","doi":"10.1186/1742-4690-10-25","title":"The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import","year":2013,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Darwin Trust of Edinburgh; Canada Research Chairs","keywords":"Cypa; Cyclophilin A; Capsid; Mutant; Biology; Viral replication; Virology; Cyclophilin; Retrovirus; HEK 293 cells; Genetics; Molecular biology; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043276,0.0002991688,0.0001776133,0.0001565599,0.0001733546,0.0002378533,0.0002727799,0.0003012088,0.001295291],"category_scores_gemma":[0.0001362234,0.00015603,0.0002751595,0.0001238577,0.0002349408,0.00007417775,0.0001986231,0.0004945893,0.0004754014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003047045,"about_ca_system_score_gemma":0.0001928142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008216093,"about_ca_topic_score_gemma":0.0008551588,"domain_scores_codex":[0.9998608,0.00002970882,0.00001670998,0.00002618366,0.00003616927,0.00003048827],"domain_scores_gemma":[0.9998542,0.00002720352,0.00005352558,0.00002392527,0.000008775472,0.00003235626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009400115,0.00004433766,0.000229762,0.00001524917,0.000007410867,0.00008883458,0.00001295647,0.0001190568,0.99858,0.00008691455,0.00003834793,0.0006831667],"study_design_scores_gemma":[0.00003430025,0.0004563055,0.006239102,0.00001164011,0.00001994993,0.001065974,0.00003407223,0.001751947,0.9884266,0.00003961845,0.001912417,0.000008103832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980046,0.0001925304,0.0007341264,0.00003524,0.00001425749,0.00002560134,0.0001991585,0.00004832781,0.000746067],"genre_scores_gemma":[0.9974735,0.0001303459,0.0008316921,0.00003109978,0.000006224762,0.00001503464,0.0002930675,0.00002311576,0.0011958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001295291,"threshold_uncertainty_score":0.004333198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004523407131822424,"score_gpt":0.22493576551631,"score_spread":0.2204123583844876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}