{"id":"W2116332104","doi":"10.1002/jps.21250","title":"Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Pyrazinamide**A project of the International Pharmaceutical Federation FIP, Groupe BCS, www.fip.org/bcs.**This article reflects the scientific opinion of the authors and not the policies of regulating agencies.","year":2008,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Bioequivalence; Dosage form; Medicine; Active ingredient; Pharmacology; Dosing; Dissolution testing; Drug; Immediate release; Pyrazinamide; Expert opinion; Biopharmaceutics Classification System; Intensive care medicine; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":["sts"],"category_scores_codex":[0.006406809,0.0002203144,0.0003791252,0.0001696107,0.001771297,0.00009867932,0.001238812,0.0001610849,0.00007253147],"category_scores_gemma":[0.0009426831,0.0001018792,0.0003811464,0.001016029,0.006518361,0.0005154347,0.000336264,0.0007778175,0.000001818034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008279613,"about_ca_system_score_gemma":0.0004878945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007480976,"about_ca_topic_score_gemma":0.00003637762,"domain_scores_codex":[0.9961081,0.0008855017,0.00116491,0.0002801184,0.00107996,0.0004814838],"domain_scores_gemma":[0.9966483,0.001314315,0.001117699,0.0002249616,0.0005358679,0.0001588647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003133004,0.001044972,0.0967985,0.0005041768,0.0008165721,0.000008772722,0.02664009,0.004135478,0.8254125,0.01415148,0.01454037,0.0128141],"study_design_scores_gemma":[0.003288015,0.0005478848,0.02492101,0.0002415931,0.0004820396,0.0002404954,0.00475323,0.1737932,0.7528581,0.001380595,0.03717282,0.0003209909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841831,0.001201488,0.00008076133,0.009995387,0.003306413,0.0008271278,0.00008882705,0.00001015429,0.0003066843],"genre_scores_gemma":[0.9979456,0.0005534617,0.0001233026,0.0008414431,0.0002949997,0.00001568743,0.00000175797,0.000009854941,0.0002138996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1696577,"threshold_uncertainty_score":0.9995283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2624358118171178,"score_gpt":0.4762894166106461,"score_spread":0.2138536047935283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}