{"id":"W2116344367","doi":"10.1517/14728222.2010.531014","title":"Paving the way for targeting RSK in cancer","year":2010,"lang":"en","type":"article","venue":"Expert Opinion on Therapeutic Targets","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Kinase; Ribosomal s6 kinase; MAPK/ERK pathway; Biology; Cell biology; Motility; Cancer cell; Cancer; Signal transduction; Phosphorylation; Cell growth; Protein kinase A; p38 mitogen-activated protein kinases; Cancer research; PI3K/AKT/mTOR pathway; Biochemistry; Genetics; P70-S6 Kinase 1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007077779,0.0005319881,0.0006925631,0.0004789805,0.0003503351,0.00102229,0.0006156344,0.001870084,0.004269814],"category_scores_gemma":[0.0003099949,0.0002601118,0.0004301583,0.0003573397,0.0007247018,0.001673805,0.000590319,0.002141343,0.00199711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007507342,"about_ca_system_score_gemma":0.000798227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005366944,"about_ca_topic_score_gemma":0.001552174,"domain_scores_codex":[0.9997979,0.00006720517,0.00001390747,0.00002812447,0.00004392061,0.00004893441],"domain_scores_gemma":[0.9998666,0.00004014956,0.00002059596,0.000009648335,0.00002781262,0.00003516327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001227795,0.0006390624,0.001253368,0.003877709,0.0001339393,0.002214296,0.0002867751,0.003803052,0.2105907,0.03437115,0.05447247,0.6871297],"study_design_scores_gemma":[0.0005876507,0.001859485,0.002392999,0.0005080162,0.0001699348,0.004193451,0.0003541394,0.003328755,0.06062911,0.03318923,0.8927045,0.00008270248],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.04768118,0.8188811,0.03347852,0.06881848,0.003547285,0.0002754012,0.0003160969,0.0005926203,0.02640947],"genre_scores_gemma":[0.1898826,0.7416605,0.03008663,0.01581628,0.002914686,0.0002936682,0.0004376172,0.00008199573,0.01882592],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.004269814,"threshold_uncertainty_score":0.01428396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02663451962857396,"score_gpt":0.3191142896636318,"score_spread":0.2924797700350578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}