{"id":"W2116344367","doi":"10.1517/14728222.2010.531014","title":"Paving the way for targeting RSK in cancer","year":2010,"lang":"en","type":"article","venue":"Expert Opinion on Therapeutic Targets","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Kinase; Ribosomal s6 kinase; MAPK/ERK pathway; Biology; Cell biology; Motility; Cancer cell; Cancer; Signal transduction; Phosphorylation; Cell growth; Protein kinase A; p38 mitogen-activated protein kinases; Cancer research; PI3K/AKT/mTOR pathway; Biochemistry; Genetics; P70-S6 Kinase 1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002697276,0.0001568386,0.0001169075,0.00003011331,0.000141098,0.00002120167,0.0002340099,0.0001439459,0.00007859799],"category_scores_gemma":[0.00005306832,0.0001078885,0.00008504595,0.00004766875,0.00004452095,0.00000358965,0.00004032567,0.0001573355,0.000006727386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001079376,"about_ca_system_score_gemma":0.00004581767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004322137,"about_ca_topic_score_gemma":0.00006764598,"domain_scores_codex":[0.9990655,0.00004786273,0.0001795167,0.0003077981,0.00009907208,0.0003002588],"domain_scores_gemma":[0.9995106,0.00004547025,0.00006432106,0.0002924612,0.00003894694,0.00004813944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009646661,0.00006637235,0.0006323371,0.000005410764,0.00002350761,4.08757e-7,0.0004414724,0.00001668864,0.951399,0.00128797,0.004859795,0.04117057],"study_design_scores_gemma":[0.0004894678,0.0001621801,0.001038835,0.00001006562,9.066551e-7,0.000001717504,0.0001358855,0.0002166909,0.2483978,0.0002246504,0.7491621,0.0001596068],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7903795,0.1475563,0.0107787,0.01705918,0.02524626,0.003969853,0.0001523076,0.0001708672,0.00468703],"genre_scores_gemma":[0.9935662,0.00126602,0.000587161,0.002496576,0.001379134,0.0003649911,0.00008269601,0.00003515526,0.0002221137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7443024,"threshold_uncertainty_score":0.4399564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02663451962857396,"score_gpt":0.3191142896636318,"score_spread":0.2924797700350578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}