{"id":"W2116355203","doi":"10.1016/j.molonc.2014.03.006","title":"Mass spectrometry based biomarker discovery, verification, and validation — Quality assurance and control of protein biomarker assays","year":2014,"lang":"en","type":"review","venue":"Molecular Oncology","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":234,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia; University of Victoria","funders":"","keywords":"Proteomics; Shotgun proteomics; Biomarker; Quantitative proteomics; Biomarker discovery; Mass spectrometry; Computational biology; Label-free quantification; Chemistry; Bioinformatics; Biology; Chromatography; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006890206,0.0003620485,0.001344989,0.0001353249,0.00006857535,0.00003750383,0.0002409823,0.0006075718,0.00004624978],"category_scores_gemma":[0.0002650738,0.0003412729,0.0001999944,0.0002321393,0.0002489296,0.00006457272,0.00005771582,0.0002776155,0.000002537533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001608189,"about_ca_system_score_gemma":0.0002213434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001847127,"about_ca_topic_score_gemma":0.000001388345,"domain_scores_codex":[0.9977662,0.0003343542,0.0008420944,0.0006546026,0.0001706535,0.0002320714],"domain_scores_gemma":[0.9976413,0.0003613557,0.001096972,0.0007136271,0.0001056795,0.00008109196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006661624,0.0001781627,0.00007269351,0.01693641,0.0002836263,0.000008258448,0.000004238302,0.000001218964,0.6246981,0.008944928,0.0000485035,0.3487573],"study_design_scores_gemma":[0.001268488,0.0001084773,0.0000460564,0.002104192,0.0006841642,0.0000285257,0.000005059075,0.0002299104,0.06722635,0.004590116,0.9229224,0.0007863099],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.0002448299,0.3853079,0.6120032,0.0001224727,0.00001306904,0.0008620889,0.0002187699,0.00004770925,0.001179968],"genre_scores_gemma":[0.03823784,0.8316291,0.1259124,0.00009038021,0.00005694678,0.002841449,0.0008676405,0.0001465333,0.0002176829],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.9228739,"threshold_uncertainty_score":0.9999039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0276095856525099,"score_gpt":0.355413783946038,"score_spread":0.3278041982935281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}