{"id":"W2116391487","doi":"10.1242/dmm.014001","title":"The role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channels","year":2014,"lang":"en","type":"review","venue":"Disease Models & Mechanisms","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; U.S. Public Health Service","keywords":"Endoplasmic-reticulum-associated protein degradation; Chaperone (clinical); Endoplasmic reticulum; Cell biology; Protein folding; Co-chaperone; Ion channel; Proteostasis; Transmembrane protein; Cytosol; Transmembrane channels; Biology; Transport protein; Chemistry; Unfolded protein response; Hsp70; Biochemistry; Voltage-gated ion channel; Heat shock protein; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002228719,0.000454075,0.0009419828,0.00006277367,0.0001535163,0.000038915,0.000503402,0.0002084404,0.000001423313],"category_scores_gemma":[0.00006209486,0.0002776927,0.0005056015,0.0001312826,0.0001370523,0.000007566522,0.0002498607,0.000126898,4.663841e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000032459,"about_ca_system_score_gemma":0.0002030753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002792374,"about_ca_topic_score_gemma":0.000007239175,"domain_scores_codex":[0.9976766,0.000309841,0.0006982411,0.0005827636,0.0003506543,0.0003818986],"domain_scores_gemma":[0.9982979,0.00006327641,0.0005467033,0.00076806,0.0000629892,0.0002610928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001134176,0.002194712,0.0001737293,0.1303741,0.002397162,0.00006629002,0.00107809,0.009197377,0.05368935,0.09823164,0.0004470831,0.7010163],"study_design_scores_gemma":[0.01609955,0.001959411,0.0001626294,0.2069658,0.02665157,0.0001227134,0.006271124,0.2365108,0.09142127,0.02552955,0.37629,0.01201552],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01925911,0.9780576,0.0007954409,0.00000968635,0.0002217492,0.0009534027,0.000653058,0.00001293324,0.00003702282],"genre_scores_gemma":[0.5123346,0.4872254,0.00000591382,0.000008942658,0.00006277177,0.0001662239,0.0001370337,0.00004320768,0.0000158174],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.6890008,"threshold_uncertainty_score":0.9999675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01035371199800512,"score_gpt":0.2385819236811716,"score_spread":0.2282282116831665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}