{"id":"W2116391487","doi":"10.1242/dmm.014001","title":"The role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channels","year":2014,"lang":"en","type":"review","venue":"Disease Models & Mechanisms","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; U.S. Public Health Service","keywords":"Endoplasmic-reticulum-associated protein degradation; Chaperone (clinical); Endoplasmic reticulum; Cell biology; Protein folding; Co-chaperone; Ion channel; Proteostasis; Transmembrane protein; Cytosol; Transmembrane channels; Biology; Transport protein; Chemistry; Unfolded protein response; Hsp70; Biochemistry; Voltage-gated ion channel; Heat shock protein; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002121364,0.000487482,0.0008220071,0.0007462671,0.0002150911,0.000666974,0.0003446524,0.0005591793,0.001201966],"category_scores_gemma":[0.0002151194,0.00009204049,0.0002886433,0.0008177509,0.0003181515,0.0008075667,0.0003414731,0.0008145347,0.0007105902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00043832,"about_ca_system_score_gemma":0.0006619412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000489122,"about_ca_topic_score_gemma":0.0006123917,"domain_scores_codex":[0.9998965,0.00001716275,0.00001637703,0.00001780509,0.00003617143,0.00001603755],"domain_scores_gemma":[0.9998933,0.00003019135,0.00001962399,0.000004005175,0.00003728852,0.00001555556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002571083,0.00007791246,0.0008099722,0.01914541,0.0001782482,0.001612411,0.0003418286,0.001069383,0.05884928,0.01140257,0.03590988,0.8703461],"study_design_scores_gemma":[0.00001359257,0.0002731962,0.003127367,0.001244723,0.0001375101,0.003803471,0.0001868814,0.0002053795,0.007794386,0.004076995,0.9791099,0.00002656479],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001114628,0.9964288,0.0004560652,0.0004040954,0.0004128889,0.000005226985,0.00002194419,0.00002143493,0.001134939],"genre_scores_gemma":[0.005391594,0.9925569,0.0003144757,0.0002259702,0.0003767121,0.00000610392,0.00004959318,0.000003022158,0.001075558],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001201966,"threshold_uncertainty_score":0.004020929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01035371199800512,"score_gpt":0.2385819236811716,"score_spread":0.2282282116831665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}