{"id":"W2116394383","doi":"10.1016/j.dnarep.2010.09.019","title":"A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation","year":2010,"lang":"en","type":"review","venue":"DNA repair","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":219,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; Canadian Institutes of Health Research; Health Canada; Alberta Innovates - Health Solutions","keywords":"DNA-PKcs; Autophosphorylation; Biology; Ku80; DNA repair; Ku70; Cell biology; DNA; DNA damage; Kinase; Protein kinase A; Biochemistry; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002915703,0.0004067593,0.0008034449,0.00007205779,0.00006869328,0.0000150342,0.0002809307,0.001019227,0.0000161478],"category_scores_gemma":[0.0001359436,0.0003718915,0.0008906546,0.00009799303,0.00006229996,0.000006539771,0.000105682,0.0001762525,0.000003891326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004418716,"about_ca_system_score_gemma":0.0002662995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004679974,"about_ca_topic_score_gemma":0.000006944565,"domain_scores_codex":[0.9981303,0.00006233994,0.0006706307,0.0006551655,0.0002070128,0.0002745722],"domain_scores_gemma":[0.9982784,0.0000256455,0.0006108691,0.0008407111,0.0001628867,0.00008147993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001165953,0.00009554967,0.000004215381,0.0101026,0.0004892732,0.000001015383,0.00008980936,0.0001374007,0.1914915,0.001719186,0.01912273,0.7766301],"study_design_scores_gemma":[0.0002787512,0.0001696017,0.000001798497,0.0004410093,0.0003377188,0.00001340866,0.000002535412,0.02165602,0.02029241,0.0004956623,0.9558675,0.0004436021],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004238083,0.9883007,0.004320615,0.00001004879,0.0004734711,0.001754367,0.0005964171,0.0001229196,0.0001833969],"genre_scores_gemma":[0.002318197,0.9586371,0.02056239,0.00005325515,0.0003946293,0.0004904791,0.008984216,0.0002371988,0.008322562],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9367447,"threshold_uncertainty_score":0.9998733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02178745368901126,"score_gpt":0.2906490396082487,"score_spread":0.2688615859192374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}