{"id":"W2116397655","doi":"10.1002/cbic.201000067","title":"Antibiotic Resistance by Enzyme Inactivation: From Mechanisms to Solutions","year":2010,"lang":"en","type":"review","venue":"ChemBioChem","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Javna Agencija za Raziskovalno Dejavnost RS; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Enzyme; Antibiotics; Antibiotic resistance; Bacteria; Mechanism (biology); Chemistry; Microbiology; Biochemistry; Biology; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002057604,0.000698671,0.001120103,0.00008200239,0.0001857211,0.000107197,0.0008991651,0.00131704,0.00009643919],"category_scores_gemma":[0.0002878463,0.000693808,0.0004202999,0.0003189406,0.0001356941,0.000007127518,0.0003820755,0.0004944218,0.000236294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001147185,"about_ca_system_score_gemma":0.0003387924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001346098,"about_ca_topic_score_gemma":0.00004075828,"domain_scores_codex":[0.997111,0.00008160813,0.0006627686,0.001262214,0.0002678183,0.0006145874],"domain_scores_gemma":[0.9975932,0.00004783792,0.0004239743,0.001533672,0.0001323053,0.0002690045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005116325,0.0002086492,0.000002400043,0.002483343,0.0003569894,0.00000951591,0.00001961975,1.238714e-7,0.7620313,0.000644903,0.1592856,0.07490639],"study_design_scores_gemma":[0.0001072302,0.00002941987,0.000002281853,0.001417434,0.0001456553,0.000004704617,0.000009951444,1.125021e-7,0.3226838,0.00006313249,0.6750075,0.0005286858],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007922762,0.9897178,0.00473708,0.00009711662,0.0007225553,0.0007920175,0.0008317551,0.00005735908,0.002252087],"genre_scores_gemma":[0.001380975,0.9769756,0.006555563,0.000204714,0.0008216728,0.00005086387,0.004891912,0.0001819469,0.008936755],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5157219,"threshold_uncertainty_score":0.9999794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02159772247858951,"score_gpt":0.2832868065628389,"score_spread":0.2616890840842494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}