{"id":"W2116397655","doi":"10.1002/cbic.201000067","title":"Antibiotic Resistance by Enzyme Inactivation: From Mechanisms to Solutions","year":2010,"lang":"en","type":"review","venue":"ChemBioChem","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Javna Agencija za Raziskovalno Dejavnost RS; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Enzyme; Antibiotics; Antibiotic resistance; Bacteria; Mechanism (biology); Chemistry; Microbiology; Biochemistry; Biology; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008126748,0.001458168,0.001786969,0.001951764,0.0004072741,0.001349514,0.001511099,0.001805113,0.002676082],"category_scores_gemma":[0.0007356531,0.0005302606,0.0004995207,0.002466234,0.001509178,0.002572972,0.0009406157,0.003343782,0.004505417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001382975,"about_ca_system_score_gemma":0.000952165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009344563,"about_ca_topic_score_gemma":0.001399548,"domain_scores_codex":[0.9996623,0.0000481401,0.00003657015,0.00006200712,0.0001550139,0.00003593423],"domain_scores_gemma":[0.9996122,0.000166005,0.00005241607,0.0000230509,0.0001020779,0.00004421535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008950879,0.0001357144,0.0001419513,0.01399439,0.00009054636,0.000258708,0.00007614536,0.0008221127,0.01084515,0.02421055,0.06710669,0.8822285],"study_design_scores_gemma":[0.00001504379,0.00005949509,0.0001590323,0.0007149437,0.00002420589,0.0005280276,0.0000235753,0.00009704581,0.00168022,0.003549858,0.9931329,0.00001568283],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001191123,0.9962677,0.0006956916,0.0004553437,0.0004906403,0.000007013599,0.00001348469,0.0000199209,0.001931108],"genre_scores_gemma":[0.0006397434,0.9974092,0.000423863,0.0002604666,0.0001978108,0.000009912967,0.00001773422,0.000003574046,0.001037751],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002676082,"threshold_uncertainty_score":0.01003426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02159772247858951,"score_gpt":0.2832868065628389,"score_spread":0.2616890840842494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}