{"id":"W2116425029","doi":"10.4049/jimmunol.177.4.2349","title":"Vav1 Controls DAP10-Mediated Natural Cytotoxicity by Regulating Actin and Microtubule Dynamics","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"NKG2D; Cell biology; Immunological synapse; Signal transducing adaptor protein; Syk; Cytolysis; Signal transduction; Biology; Phosphorylation; Chemistry; Cytotoxicity; Tyrosine kinase; T-cell receptor; T cell; Biochemistry; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005736313,0.0001718111,0.0003495919,0.0001161754,0.0002768958,0.00002031742,0.0002328849,0.0002321835,0.0002454265],"category_scores_gemma":[0.0001828062,0.0001160017,0.00009345144,0.00007943274,0.0003300239,0.0001839663,0.00006720774,0.0009207455,0.00006607183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001102781,"about_ca_system_score_gemma":0.00003626753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002488699,"about_ca_topic_score_gemma":0.00003526427,"domain_scores_codex":[0.998453,0.0005114331,0.0005957079,0.0001077159,0.00003864606,0.000293462],"domain_scores_gemma":[0.9983846,0.0005524424,0.0006988189,0.0001764818,0.0001773501,0.00001030448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001124975,0.00007387273,0.0003299484,0.000003172216,0.0002369452,0.000001809028,0.0001418624,0.000006618277,0.9827627,0.0001321509,0.01366347,0.001522491],"study_design_scores_gemma":[0.009083159,0.001414037,0.01898156,0.00009613352,0.000279261,0.00768788,0.002812993,0.0003822318,0.8606645,0.0003602891,0.09776493,0.0004730371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774314,0.0174308,0.000446942,0.00138809,0.002602839,0.0001352222,0.000006945813,0.00002569864,0.0005320954],"genre_scores_gemma":[0.9926497,0.0003797447,0.00003068556,0.0002500365,0.00005789974,0.000001661583,0.00006486123,0.00001519275,0.006550221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1220982,"threshold_uncertainty_score":0.4730411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003910730404428227,"score_gpt":0.2012527472998308,"score_spread":0.1973420168954026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}