{"id":"W2116445953","doi":"10.15252/embj.201591382","title":"The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis","year":2015,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":235,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"Institute of Genetics; Deutsche Forschungsgemeinschaft","keywords":"Biology; Transfer RNA; Methyltransferase; Methylation; DNA methylation; Protein biosynthesis; Start codon; Genetics; RNA; Messenger RNA; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009666656,0.0002635093,0.0002271081,0.0001475847,0.0002255733,0.0003217435,0.0001420096,0.0002640943,0.0008480565],"category_scores_gemma":[0.0002046561,0.0001657304,0.0001207562,0.0001395642,0.0002323089,0.000201598,0.0002535566,0.0003353907,0.0004765733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003009576,"about_ca_system_score_gemma":0.0002757785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006128188,"about_ca_topic_score_gemma":0.001137536,"domain_scores_codex":[0.9998969,0.00001199855,0.00001002899,0.00003104615,0.00003099423,0.00001911593],"domain_scores_gemma":[0.9998652,0.00001594686,0.00004387341,0.0000179375,0.00001725747,0.00003974701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003504939,0.000001928384,0.0002902582,0.00001271867,0.000001628457,0.00004849762,0.000005887212,0.00002594784,0.9986986,0.00005169097,0.0000194182,0.0008083091],"study_design_scores_gemma":[0.000009320489,0.00006249736,0.02140822,0.000006548084,0.000009603366,0.0005465052,0.00001684522,0.0006546442,0.9733621,0.0001309795,0.003786901,0.000005793601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897152,0.002725722,0.005068844,0.0001121118,0.0000283905,0.00001359803,0.0005933699,0.0002336004,0.001509078],"genre_scores_gemma":[0.9930294,0.0007603421,0.003646824,0.00003352175,0.000009914918,0.00001131961,0.0005887264,0.00004035779,0.001879464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008480565,"threshold_uncertainty_score":0.002837002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04079079692823854,"score_gpt":0.2994699533538316,"score_spread":0.258679156425593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}