{"id":"W2116454541","doi":"10.1371/journal.pone.0077053","title":"A High-Content Small Molecule Screen Identifies Sensitivity of Glioblastoma Stem Cells to Inhibition of Polo-Like Kinase 1","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Hospital for Sick Children; Brain Tumour Charity; Cancer Research UK; Wellcome Trust","keywords":"Prometaphase; Neural stem cell; Stem cell; Biology; PLK1; Cell biology; Cancer research; Kinase; Mitosis; Cancer stem cell; Cell cycle; Cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127582,0.0001383565,0.0002526796,0.00006973428,0.00002447955,0.00001262707,0.0000812129,0.000120053,0.00001600984],"category_scores_gemma":[0.00002104682,0.0001422335,0.00008629622,0.00008374864,0.00007749446,0.000005683059,0.0001598014,0.00005542475,0.00002682001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001198455,"about_ca_system_score_gemma":0.00002433171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001274164,"about_ca_topic_score_gemma":0.0006483585,"domain_scores_codex":[0.9990603,0.00007923415,0.000278594,0.0002637866,0.0001286727,0.0001894513],"domain_scores_gemma":[0.9991177,0.00001321596,0.0001374162,0.0003441487,0.0003027726,0.0000847597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008651988,0.0006129001,0.0002127386,0.0001123748,0.0001390592,0.000003152774,0.00004620894,0.00001527147,0.9981679,0.00003189994,0.0003609288,0.0002110746],"study_design_scores_gemma":[0.0003403987,0.0004689658,0.000572886,0.0001219004,0.00006250262,0.000001495053,0.0001148575,0.00008193031,0.9980727,0.000009089324,0.0000109091,0.0001423604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979075,0.00008228828,0.00123431,0.0001129399,0.00003280836,0.0004592265,0.0001303964,0.000009878541,0.00003068939],"genre_scores_gemma":[0.9978514,0.00004775156,0.001236394,0.0002019724,0.00004821644,0.00002751535,0.00004255333,0.00002054336,0.0005236622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006258058,"threshold_uncertainty_score":0.5800114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.020874234234329,"score_gpt":0.1939064888395838,"score_spread":0.1730322546052548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}