{"id":"W2116489906","doi":"10.1152/ajpcell.00177.2009","title":"Bicarbonate homeostasis in excitable tissues: role of AE3 Cl <sup>−</sup> /HCO <sub>3</sub> <sup>−</sup> exchanger and carbonic anhydrase XIV interaction","year":2009,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Fondo para la Investigación Científica y Tecnológica; Canadian Institutes of Health Research; National Institutes of Health; Alberta Heritage Foundation for Medical Research; National Institute of Diabetes and Digestive and Kidney Diseases; Consejo Nacional de Investigaciones Científicas y Técnicas; Fondation pour la Recherche Médicale","keywords":"Intracellular pH; Chemistry; Carbonic anhydrase; Carbonic anhydrase II; Bicarbonate; Organic anion transporter 1; Homeostasis; Extracellular; Molecular biology; Ion transporter; Acetazolamide; Biochemistry; Biophysics; Cell biology; Transporter; Biology; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002072272,0.0002571832,0.0003463031,0.0002056065,0.0002253381,0.0006247221,0.0002874775,0.0004954672,0.000988176],"category_scores_gemma":[0.000155882,0.0001064694,0.0002499831,0.000198055,0.0003034944,0.0007246538,0.0004573373,0.0004788922,0.000266942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004336204,"about_ca_system_score_gemma":0.0002465093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009191354,"about_ca_topic_score_gemma":0.0009931144,"domain_scores_codex":[0.9999131,0.00001275028,0.000007205781,0.00002315391,0.00002448145,0.00001937403],"domain_scores_gemma":[0.99991,0.00000772161,0.00003010083,0.000004985779,0.00002030332,0.00002689268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003820006,0.00002147877,0.002906753,0.0004274906,0.00004541422,0.000542637,0.0001035008,0.000172378,0.9805228,0.002150991,0.0003819776,0.01234258],"study_design_scores_gemma":[0.0001202467,0.0007904319,0.1315261,0.0002374139,0.0003110345,0.008211361,0.00103093,0.00924206,0.7750484,0.008042903,0.06536889,0.00007044993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.676666,0.2809114,0.02787573,0.002871031,0.0002606755,0.00005767498,0.0006387032,0.0003434951,0.01037518],"genre_scores_gemma":[0.934674,0.05276534,0.005232031,0.0005169801,0.0001337166,0.00003655976,0.000402423,0.00003815845,0.006200701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000988176,"threshold_uncertainty_score":0.003305793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005887208316363303,"score_gpt":0.2239245594782929,"score_spread":0.2180373511619296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}