{"id":"W2116491845","doi":"10.2147/dddt.s90170","title":"Therapeutic designed poly (lactic-co-glycolic acid) cylindrical oseltamivir phosphate-loaded implants impede tumor neovascularization, growth and metastasis in mouse model of human pancreatic carcinoma","year":2015,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"PLGA; Neovascularization; Pancreatic cancer; Metastasis; Cancer research; Irinotecan; Medicine; In vivo; Angiogenesis; Pharmacology; Colorectal cancer; Pathology; Chemistry; In vitro; Cancer; Internal medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003955256,0.0002685071,0.0003378327,0.0001436576,0.0001116123,0.00004882691,0.0001456035,0.00008012819,0.000003986099],"category_scores_gemma":[0.00002126111,0.0002263398,0.00004673169,0.0001433019,0.00008949558,0.00002181274,0.00004769869,0.00007923144,0.000001270809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004110235,"about_ca_system_score_gemma":0.0003863103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002012862,"about_ca_topic_score_gemma":0.00003723372,"domain_scores_codex":[0.9984431,0.0002035343,0.000322843,0.0004034975,0.0002609605,0.0003661245],"domain_scores_gemma":[0.9993899,0.00002559734,0.0001028413,0.0001980039,0.0000795207,0.0002041792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00201327,0.0003977419,0.04412458,0.00004655595,0.0006509381,0.00002179798,0.002587642,0.00001174471,0.9293048,0.00009373944,0.00004463086,0.02070254],"study_design_scores_gemma":[0.00468167,0.0003123881,0.00439563,0.00000979801,0.00002606204,0.00001173914,0.0001336581,0.0002309138,0.9895337,0.0003737836,0.00003561929,0.0002550631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798664,0.0129256,0.006545084,0.00002810631,0.00001117006,0.0005504349,0.00001417088,0.0000122648,0.00004669584],"genre_scores_gemma":[0.995763,0.0009401682,0.002772984,0.0001046961,0.00001573544,0.0001343642,0.00009663984,0.00003530407,0.000137128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06022885,"threshold_uncertainty_score":0.922987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04500067962431849,"score_gpt":0.2832978414799919,"score_spread":0.2382971618556735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}