{"id":"W2116510961","doi":"10.1128/jvi.00862-11","title":"Membrane Perturbation Elicits an IRF3-Dependent, Interferon-Independent Antiviral Response","year":2011,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"IRF3; Biology; Interferon; Innate immune system; Lipid bilayer fusion; Viral envelope; Virus; Virology; Transmembrane protein; Cell biology; Antiviral protein; Interferon regulatory factors; Viral entry; Immune system; Viral replication; Immunology; RNA; Gene; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001614135,0.000240979,0.0005147612,0.0004915582,0.0001162927,0.00001624384,0.0005471266,0.0004341703,0.00208984],"category_scores_gemma":[0.0003212006,0.0001923368,0.0002014892,0.00008373069,0.0002387004,0.0004157282,0.0001039313,0.0007610092,0.0004602114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007664686,"about_ca_system_score_gemma":0.0001322695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003154738,"about_ca_topic_score_gemma":0.00001994638,"domain_scores_codex":[0.9965301,0.001937259,0.0007939306,0.0002361249,0.00007892021,0.0004236889],"domain_scores_gemma":[0.9985905,0.0002362982,0.0005710679,0.0003228974,0.0002292931,0.00004997331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04524119,0.0004577928,0.0004715512,0.000005352186,0.0002515223,0.0001212403,0.002442604,0.000001424553,0.9476754,0.0004332336,0.0005084444,0.002390226],"study_design_scores_gemma":[0.003797333,0.01321922,0.03574945,0.00004121651,0.0001230556,0.004381536,0.0009830785,0.000009428361,0.9317849,0.0002806086,0.009339822,0.000290336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942448,0.0008534335,0.0005631398,0.0002991495,0.002123652,0.0001096239,0.000009860016,0.00002949212,0.001766854],"genre_scores_gemma":[0.9948313,0.0001381553,0.0001060683,0.0005016076,0.00008186097,0.000003070704,0.000007410633,0.00002741358,0.004303124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04144386,"threshold_uncertainty_score":0.9988224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02833331113360998,"score_gpt":0.2597119648885123,"score_spread":0.2313786537549024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}