{"id":"W2116510961","doi":"10.1128/jvi.00862-11","title":"Membrane Perturbation Elicits an IRF3-Dependent, Interferon-Independent Antiviral Response","year":2011,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"IRF3; Biology; Interferon; Innate immune system; Lipid bilayer fusion; Viral envelope; Virus; Virology; Transmembrane protein; Cell biology; Antiviral protein; Interferon regulatory factors; Viral entry; Immune system; Viral replication; Immunology; RNA; Gene; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002507867,0.0003611813,0.0002470451,0.0001381012,0.0001825209,0.0002856124,0.0001100504,0.0003751604,0.001454136],"category_scores_gemma":[0.0002338634,0.0001310662,0.0003126963,0.00008291042,0.0001990375,0.0002517097,0.000319573,0.0006525317,0.0004705942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004218788,"about_ca_system_score_gemma":0.0001693405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001986424,"about_ca_topic_score_gemma":0.000300451,"domain_scores_codex":[0.9997795,0.00004318322,0.00001533597,0.00002950842,0.00005050522,0.00008189664],"domain_scores_gemma":[0.9998405,0.00004718733,0.0000325251,0.00003094278,0.00002219314,0.00002658171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005428036,0.000009244989,0.0001077991,0.00000879694,0.000001518373,0.00002021916,0.000004804331,0.00001960286,0.9994223,0.00004257874,0.00001164978,0.0002971345],"study_design_scores_gemma":[0.00001293707,0.0001812862,0.003828227,0.00000420588,0.000006337898,0.0002678779,0.00003924413,0.0009437639,0.9938273,0.0001104691,0.0007734912,0.000004936417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965532,0.0003178046,0.001993683,0.00007192347,0.00001704199,0.00001971961,0.000193451,0.0000410229,0.0007922722],"genre_scores_gemma":[0.9972199,0.0001556184,0.001620471,0.00004727778,0.000006705607,0.00001815923,0.000264715,0.000009969568,0.0006572524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001454136,"threshold_uncertainty_score":0.004864573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02833331113360998,"score_gpt":0.2597119648885123,"score_spread":0.2313786537549024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}