{"id":"W2116568632","doi":"10.1152/ajpcell.00305.2012","title":"Elevated SOCS3 and altered IL-6 signaling is associated with age-related human muscle stem cell dysfunction","year":2013,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"SOCS3; Internal medicine; Endocrinology; Cytokine; STAT protein; STAT3; Signal transduction; Interleukin 6; Medicine; Biology; Chemistry; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001493796,0.0002723594,0.0003152989,0.0003964236,0.0001576095,0.000141958,0.00007559545,0.0001606274,0.001141232],"category_scores_gemma":[0.0001997131,0.0001314777,0.0001578895,0.0002233152,0.000188103,0.00009464727,0.0002145802,0.0001442849,0.0001150982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001125512,"about_ca_system_score_gemma":0.00009018849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007415324,"about_ca_topic_score_gemma":0.001020625,"domain_scores_codex":[0.9999232,0.00001161531,0.000009501936,0.00002194843,0.00001554536,0.00001819863],"domain_scores_gemma":[0.9998142,0.00001266083,0.00009385972,0.00001160708,0.000017293,0.00005048602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005077135,0.0002184399,0.4287522,0.00009801107,0.00007272168,0.001162978,0.0002641405,0.0001551818,0.5561395,0.0000626505,0.0001251199,0.007871928],"study_design_scores_gemma":[0.00001810974,0.001107166,0.9888052,0.000003858898,0.00002434927,0.001182568,0.00008043068,0.0002553353,0.008293403,0.00004159185,0.000183832,0.000004194919],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996743,0.0001061001,0.0001098098,0.000003831762,0.000001337119,0.000003178543,0.00004602131,0.000002718168,0.00005269561],"genre_scores_gemma":[0.9995106,0.0000552001,0.00009432423,0.00001014981,0.000003728465,0.000006339569,0.000146294,0.00000101776,0.0001724308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001141232,"threshold_uncertainty_score":0.003817737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005834820945034676,"score_gpt":0.2038626914342572,"score_spread":0.1980278704892225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}