{"id":"W2116573438","doi":"10.1242/jcs.01201","title":"CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells","year":2004,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; School of Medicine, New York University; York University","keywords":"Biology; Annexin; Cell biology; p38 mitogen-activated protein kinases; Apoptosis; MAPK/ERK pathway; Kinase; Tetraspanin; Cancer cell; Phosphorylation; Protein kinase A; Programmed cell death; Molecular biology; Cell; Cancer; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007811788,0.0002184957,0.0001720333,0.0001381331,0.0001943862,0.0001889127,0.00009438698,0.0002124198,0.001129329],"category_scores_gemma":[0.0001024262,0.00007686317,0.0001889086,0.0001438047,0.000145574,0.0001550032,0.0001201627,0.0005535635,0.0003307573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296315,"about_ca_system_score_gemma":0.0001232798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003716447,"about_ca_topic_score_gemma":0.0003894004,"domain_scores_codex":[0.9998778,0.00002045113,0.00001363246,0.0000188001,0.00003506348,0.00003424584],"domain_scores_gemma":[0.9999353,0.0000124766,0.0000140949,0.00001133633,0.000009447421,0.00001737125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001577731,0.0000350779,0.0002058438,0.00002327315,0.000003801956,0.00009454932,0.000007225897,0.00004882281,0.9982507,0.000064579,0.00004600212,0.001062383],"study_design_scores_gemma":[0.00001929684,0.0002444898,0.003077704,0.000002216891,0.000007328606,0.0004419857,0.00001656706,0.00104924,0.9936749,0.00003420771,0.001430267,0.000001692126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961079,0.0009839503,0.001452554,0.00009117273,0.00003612021,0.00002023434,0.000154978,0.0000311649,0.001121865],"genre_scores_gemma":[0.9968275,0.0006546063,0.000724439,0.00003189645,0.00001024976,0.00001799407,0.0003598886,0.000003452433,0.001369865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001129329,"threshold_uncertainty_score":0.003777981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0229702176195882,"score_gpt":0.3266712990482955,"score_spread":0.3037010814287073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}