{"id":"W2116585082","doi":"10.1139/o04-054","title":"Role of Serine 286 in cosubstrate binding and catalysis of a flavonol <i>O</i>-methyltransferase","year":2004,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Plant Gene Expression Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"O-methyltransferase; Stereochemistry; Chemistry; Methyltransferase; Biochemistry; Cofactor; Active site; Serine; Methylation; Homotetramer; Binding site; Pterin; Isothermal titration calorimetry; Circular dichroism; Tetranitromethane; Enzyme; Protein subunit; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211735,0.0001395442,0.0002577197,0.00006003201,0.00002123717,0.000003290361,0.000105906,0.000221413,0.00000913536],"category_scores_gemma":[0.00002241184,0.0001310596,0.00005877581,0.0001232589,0.0001666625,0.00000239442,0.000069748,0.0000681445,4.53316e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005186458,"about_ca_system_score_gemma":0.00004869268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007824904,"about_ca_topic_score_gemma":0.00003939075,"domain_scores_codex":[0.9991755,0.00002956915,0.0002758093,0.0003244585,0.00003512738,0.0001595573],"domain_scores_gemma":[0.9995924,0.00001053447,0.0001011931,0.0001964828,0.00002991682,0.00006947901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007296308,0.00007759373,0.004643735,0.00007215479,0.00004088578,0.000001967654,0.00003789923,0.00002412853,0.9942828,0.00001101658,0.000008607647,0.0007262897],"study_design_scores_gemma":[0.000743075,0.0001051427,0.0002979253,0.00002033746,0.0000319249,0.00001035819,0.0001783432,0.000009154863,0.9980714,0.00005911474,0.0003427599,0.0001304056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966639,0.002497572,0.00003579448,0.00002451847,0.000009276354,0.00005530563,0.00009738177,0.000003203238,0.0006129973],"genre_scores_gemma":[0.9973306,0.001970023,0.0002734383,0.00001738463,0.00001871003,0.00000656498,0.000290742,0.000006853756,0.00008568271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00434581,"threshold_uncertainty_score":0.5344456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003557662121292904,"score_gpt":0.2075378137821255,"score_spread":0.2039801516608326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}