{"id":"W2116587698","doi":"10.3390/antibiotics4010113","title":"Purification of a Multidrug Resistance Transporter for Crystallization Studies","year":2015,"lang":"en","type":"article","venue":"Antibiotics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast; Biotechnology and Biological Sciences Research Council; University of St Andrews","keywords":"Major facilitator superfamily; Crystallization; Integral membrane protein; Efflux; Recombinant DNA; Membrane protein; Chemistry; Transporter; Biochemistry; Multiple drug resistance; Target protein; Protein crystallization; Chromatography; Membrane; Biology; Gene; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006904553,0.0004135271,0.000899809,0.0003999165,0.0006819701,0.0004366852,0.0004778896,0.0004709667,0.0027075],"category_scores_gemma":[0.0006231442,0.0002501672,0.0004485931,0.0009904584,0.0002176695,0.0004603107,0.0004138574,0.0008373712,0.001888225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005832918,"about_ca_system_score_gemma":0.0005953696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001307486,"about_ca_topic_score_gemma":0.001773731,"domain_scores_codex":[0.9996578,0.00005552239,0.00005745058,0.00005900675,0.0001169097,0.00005338212],"domain_scores_gemma":[0.9997879,0.00003471212,0.00001844634,0.00004051243,0.00009193187,0.00002656176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004344395,0.0000542979,0.0002946586,0.0001094106,0.000009874001,0.0001156166,0.00004884669,0.000169453,0.9955362,0.0003854486,0.0004724128,0.002760366],"study_design_scores_gemma":[0.00003305818,0.0001762312,0.002393233,0.00002637808,0.00001949585,0.0004421645,0.00006921402,0.003521251,0.9654151,0.0002591958,0.02763054,0.00001408791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7587022,0.004216044,0.2051216,0.001528353,0.0004119922,0.003583728,0.01299633,0.001740535,0.01169922],"genre_scores_gemma":[0.6887792,0.006044706,0.2541019,0.0003747712,0.0001115301,0.001757544,0.0288867,0.0004319617,0.01951172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0027075,"threshold_uncertainty_score":0.009057522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0833352931328874,"score_gpt":0.3364822892884602,"score_spread":0.2531469961555728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}