{"id":"W2116587698","doi":"10.3390/antibiotics4010113","title":"Purification of a Multidrug Resistance Transporter for Crystallization Studies","year":2015,"lang":"en","type":"article","venue":"Antibiotics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast; Biotechnology and Biological Sciences Research Council; University of St Andrews","keywords":"Major facilitator superfamily; Crystallization; Integral membrane protein; Efflux; Recombinant DNA; Membrane protein; Chemistry; Transporter; Biochemistry; Multiple drug resistance; Target protein; Protein crystallization; Chromatography; Membrane; Biology; Gene; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002058724,0.000089901,0.0002485771,0.00005472704,0.00002817673,0.000003107707,0.00004444789,0.00006204088,0.000001598321],"category_scores_gemma":[0.00004966116,0.00007331341,0.00007332701,0.0001267798,0.00006841232,0.00005114887,0.000002106207,0.00003731627,0.000001616604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002505814,"about_ca_system_score_gemma":0.00006608471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001499912,"about_ca_topic_score_gemma":0.00006224991,"domain_scores_codex":[0.9992543,0.000007533164,0.0002813191,0.0001504303,0.0001850331,0.0001213527],"domain_scores_gemma":[0.9991926,0.00002026034,0.0001009583,0.0001824158,0.0004404495,0.00006331479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005532829,0.002319134,0.0694082,0.0114177,0.001252853,0.00008482172,0.02527513,0.000299327,0.7977619,0.06838628,0.01472966,0.003532134],"study_design_scores_gemma":[0.006576826,0.0005053995,0.01508157,0.001110005,0.0008524717,0.00000568109,0.005043038,0.0006324924,0.9313884,0.004260616,0.03414492,0.0003986206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7854939,0.003136976,0.2049811,0.001978418,0.0006016144,0.0015056,0.00007553621,0.000121788,0.002105048],"genre_scores_gemma":[0.9601643,0.0002785888,0.03624811,0.00006643971,0.00006020274,0.000001086923,0.00009908889,0.00001815422,0.003064009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1746705,"threshold_uncertainty_score":0.2989634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0833352931328874,"score_gpt":0.3364822892884602,"score_spread":0.2531469961555728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}